Identification of IDH and TERTp mutations using dynamic susceptibility contrast MRI with deep learning in 162 gliomas.

Journal: European journal of radiology
Published Date: Dec 13, 2023

Abstract

PURPOSE: Isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase gene promoter (TERTp) mutations play crucial roles in glioma biology. Such genetic information is typically obtained invasively from excised tumor tissue; however, these mutations need to be identified preoperatively for better treatment planning. The relative cerebral blood volume (rCBV) information derived from dynamic susceptibility contrast MRI (DSC-MRI) has been demonstrated to correlate with tumor vascularity, functionality, and biology, and might provide some information about the genetic alterations in gliomas before surgery. Therefore, this study aims to predict IDH and TERTp mutational subgroups in gliomas using deep learning applied to rCBV images.

Authors

  • Buse Buz-Yalug
    Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey.
  • Gulce Turhan
    Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey.
  • Ayse Irem Cetin
    Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey.
  • Sukru Samet Dindar
    Electrical and Electronics Engineering Department, Bogazici University, Istanbul, Turkey.
  • Ayca Ersen Danyeli
    Department of Medical Pathology, Acibadem University, Istanbul, Turkey; Center for Neuroradiological Applications and Research, Acibadem University, Istanbul, Turkey.
  • Cengiz Yakicier
    Department of Molecular Biology and Genetics, Acibadem University, Istanbul, Turkey.
  • M Necmettin Pamir
    Center for Neuroradiological Applications and Research, Acibadem University, Istanbul, Turkey; Department of Neurosurgery, Acibadem University, Istanbul, Turkey.
  • Koray Özduman
    Center for Neuroradiological Applications and Research, Acibadem University, Istanbul, Turkey; Department of Neurosurgery, Acibadem University, Istanbul, Turkey.
  • Alp Dincer
    Center for Neuroradiological Applications and Research, Acibadem University, Istanbul, Turkey; Department of Radiology, Acıbadem University, Istanbul, Turkey.
  • Esin Ozturk-Isik
    Biomedical Engineering Institute, Boğaziçi University, Istanbul, Turkey.

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