Clinical Outcomes in Patients With Gram-Negative Infections Treated With Optimized Dosing Cefepime Over Various Minimum Inhibitory Concentrations.

Journal: Journal of pharmacy practice
PMID: 29278990

Abstract

BACKGROUND: The Clinical and Laboratory Standards Institute (CLSI) revised cefepime interpretive criteria, introducing the susceptible dose-dependent category for Enterobacteriaceae with a minimum inhibitory concentration (MIC) of 4 to 8 μg/mL in 2014. Limited clinical data support these new categories. This study compares outcomes of patients treated with standard and high-dose cefepime across various MICs.

Authors

  • Jerry Altshuler
    1 Pharmacy Department, Mount Sinai Beth Israel, New York, NY, USA.
  • David J Guervil
    2 Department of Pharmacy, Memorial Hermann-Texas Medical Center, Houston, TX, USA.
  • Charles D Ericsson
    3 Division of Infectious Diseases, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Audrey Wanger
    4 Department of Pathology, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Samuel L Aitken
    5 Division of Pharmacy, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Luis Ostrosky-Zeichner
    3 Division of Infectious Diseases, University of Texas Health Science Center at Houston, Houston, TX, USA.

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