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Gram-Negative Bacterial Infections

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In vitro activity of eravacycline against 2213 Gram-negative and 2424 Gram-positive bacterial pathogens isolated in Canadian hospital laboratories: CANWARD surveillance study 2014-2015.

Diagnostic microbiology and infectious disease 29338931
Gram-negative (n=2213) and Gram-positive (n=2424) pathogens isolated from patients in 13 Canadian hospitals in 2014 and 2015 were tested for in vitro susceptibility to eravacycline and comparators using the Clinical and Laboratory Standards Institute...
Anti-Bacterial Agents Canada Enterobacteriaceae Enterobacteriaceae Infections Epidemiological Monitoring Gram-Negative Bacteria Gram-Negative Bacterial Infections Gram-Positive Bacteria Gram-Positive Bacterial Infections Humans Laboratories, Hospital Microbial Sensitivity Tests Tetracyclines
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Clinical Outcomes in Patients With Gram-Negative Infections Treated With Optimized Dosing Cefepime Over Various Minimum Inhibitory Concentrations.

Journal of pharmacy practice 29278990
BACKGROUND: The Clinical and Laboratory Standards Institute (CLSI) revised cefepime interpretive criteria, introducing the susceptible dose-dependent category for Enterobacteriaceae with a minimum inhibitory concentration (MIC) of 4 to 8 μg/mL in 201...
Adult Aged Anti-Bacterial Agents Cefepime Cephalosporins Cohort Studies Dose-Response Relationship, Drug Enterobacteriaceae Enterobacteriaceae Infections Female Gram-Negative Bacterial Infections Humans Male Microbial Sensitivity Tests Middle Aged Retrospective Studies Treatment Outcome
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High procalcitonin level is related to blood stream infections, gram-negative pathogens, and ICU admission in infections of adult febrile cancer patients.

Journal of the Egyptian National Cancer Institute 40346417
BACKGROUND: Blood stream infection (BSI) represent a life-threatening condition. Thus, we aimed to investigate the role of procalcitonin (PCT) and C-reactive protein (CRP) tests in adult febrile patients with BSI and other clinical infections in hosp...
Adult Aged Bacteremia Biomarkers Blood Culture C-Reactive Protein Female Fever Gram-Negative Bacteria Gram-Negative Bacterial Infections Humans Intensive Care Units Male Middle Aged Neoplasms Procalcitonin
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Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections.

Kidney international 28318629
The immune system has evolved to sense invading pathogens, control infection, and restore tissue integrity. Despite symptomatic variability in patients, unequivocal evidence that an individual's immune system distinguishes between different organisms...
Acute Disease Adolescent Adult Aged Aged, 80 and over Area Under Curve Bacteria Biomarkers Case-Control Studies Female Gram-Negative Bacterial Infections Gram-Positive Bacterial Infections Host-Pathogen Interactions Humans Machine Learning Male Middle Aged Nonlinear Dynamics Pattern Recognition, Automated Peptide Mapping Peritoneal Dialysis Peritonitis Point-of-Care Systems Point-of-Care Testing Predictive Value of Tests Reproducibility of Results ROC Curve Time Factors Young Adult
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Estimating the association between antibiotic exposure and colonization with extended-spectrum β-lactamase-producing Gram-negative bacteria using machine learning methods: a multicentre, prospective cohort study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 31128285
OBJECTIVES: The aim of the study was to measure the impact of antibiotic exposure on the acquisition of colonization with extended-spectrum β-lactamase-producing Gram-negative bacteria (ESBL-GNB) accounting for individual- and group-level confounding...
Adolescent Adult Aged Anti-Bacterial Agents beta-Lactamases Drug Therapy, Combination Female Gram-Negative Bacteria Gram-Negative Bacterial Infections Hospitalization Humans Incidence Italy Machine Learning Male Middle Aged Prospective Studies Risk Factors Romania Serbia Young Adult
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Machine Learning Algorithms Identify Pathogen-Specific Biomarkers of Clinical and Metabolomic Characteristics in Septic Patients with Bacterial Infections.

BioMed research international 32802867
Sepsis is a high-mortality disease that is infected by bacteria, but pathogens in individual patients are difficult to diagnosis. Metabolomic changes triggered by microbial activity provide us with the possibility of accurately identifying infection....
Aged Biomarkers Databases, Factual Diagnosis, Computer-Assisted Female Gram-Negative Bacterial Infections Gram-Positive Bacterial Infections Humans Machine Learning Male Middle Aged Sepsis
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Machine learning algorithms to predict colistin-induced nephrotoxicity from electronic health records in patients with multidrug-resistant Gram-negative infection.

International journal of antimicrobial agents 38642812
OBJECTIVES: Colistin-induced nephrotoxicity prolongs hospitalisation and increases mortality. The study aimed to construct machine learning models to predict colistin-induced nephrotoxicity in patients with multidrug-resistant Gram-negative infection...
Adult Aged Algorithms Anti-Bacterial Agents Colistin Drug Resistance, Multiple, Bacterial Electronic Health Records Female Gram-Negative Bacterial Infections Humans Machine Learning Male Middle Aged Retrospective Studies ROC Curve
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Prediction of carbapenem-resistant gram-negative bacterial bloodstream infection in intensive care unit based on machine learning.

BMC medical informatics and decision making 38745177
BACKGROUND: Predicting whether Carbapenem-Resistant Gram-Negative Bacterial (CRGNB) cause bloodstream infection when giving advice may guide the use of antibiotics because it takes 2-5 days conventionally to return the results from doctor's order.
Adult Aged Anti-Bacterial Agents Bacteremia Carbapenems Drug Resistance, Bacterial Female Gram-Negative Bacteria Gram-Negative Bacterial Infections Humans Intensive Care Units Machine Learning Male Middle Aged Retrospective Studies
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Innovative strategies against superbugs: Developing an AI-CDSS for precise Stenotrophomonas maltophilia treatment.

Journal of global antimicrobial resistance 38909685
OBJECTIVES: The World Health Organization named Stenotrophomonas maltophilia (SM) a critical multi-drug resistant threat, necessitating rapid diagnostic strategies. Traditional culturing methods require up to 96 h, including 72 h for bacterial growth...
Anti-Bacterial Agents Artificial Intelligence Decision Support Systems, Clinical Drug Resistance, Multiple, Bacterial Gram-Negative Bacterial Infections Humans Levofloxacin Machine Learning Microbial Sensitivity Tests Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Stenotrophomonas maltophilia Trimethoprim, Sulfamethoxazole Drug Combination
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A novel machine-learning aided platform for rapid detection of urine ESBLs and carbapenemases: URECA-LAMP.

Journal of clinical microbiology 39445836
Pathogenic gram-negative bacteria frequently carry genes encoding extended-spectrum beta-lactamases (ESBL) and/or carbapenemases. Of great concern are carbapenem resistant , , and . Despite the need for rapid AMR diagnostics globally, current molecu...
Acinetobacter baumannii Bacterial Proteins beta-Lactamases Gram-Negative Bacteria Gram-Negative Bacterial Infections Humans Machine Learning Molecular Diagnostic Techniques Nucleic Acid Amplification Techniques Sensitivity and Specificity Smartphone
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