Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis.

Journal: Frontiers in immunology
PMID: 38426100

Abstract

This review explores the mechanisms of chronic radiation-induced skin injury fibrosis, focusing on the transition from acute radiation damage to a chronic fibrotic state. It reviewed the cellular and molecular responses of the skin to radiation, highlighting the role of myofibroblasts and the significant impact of Transforming Growth Factor-beta (TGF-β) in promoting fibroblast-to-myofibroblast transformation. The review delves into the epigenetic regulation of fibrotic gene expression, the contribution of extracellular matrix proteins to the fibrotic microenvironment, and the regulation of the immune system in the context of fibrosis. Additionally, it discusses the potential of biomaterials and artificial intelligence in medical research to advance the understanding and treatment of radiation-induced skin fibrosis, suggesting future directions involving bioinformatics and personalized therapeutic strategies to enhance patient quality of life.

Authors

  • Yiren Wang
    Department of Electrical and Computer Engineering, University of Washington, 98195, Seattle, WA, USA. ethanwyr@uw.edu.
  • Shouying Chen
    School of Nursing, Southwest Medical University, Luzhou, China.
  • Shuilan Bao
    School of Nursing, Southwest Medical University, Luzhou, China.
  • Li Yao
    College of Information Science and Technology, Beijing Normal University, Beijing, China.
  • Zhongjian Wen
    School of Nursing, Southwest Medical University, Luzhou, China.
  • Lixia Xu
    Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangdong, 510000, China.
  • Xiaoman Chen
    School of Nursing, Southwest Medical University, Luzhou, China.
  • Shengmin Guo
    Department of Nursing, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Haowen Pang
    Department of Oncology, The Affiliated Hospital of Southwest Medical University, Sichuan, China.
  • Yun Zhou
    MOE Key Lab of Environmental and Occupational Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
  • Ping Zhou

Keywords

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