AIMC Topic: Fibrosis
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Identification of potential pathogenic genes associated with the comorbidity of rheumatoid arthritis and renal fibrosis using bioinformatics and machine learning.
Scientific reports
Jul 1, 2025
This study aimed to identify the potential pathogenic genes associated with the comorbidity of rheumatoid arthritis (RA) and renal fibrosis (RF). Transcriptomic data related to RA and RF were retrieved from the GEO database. Differential expression g...
Development and validation of multi-center serum creatinine-based models for noninvasive prediction of kidney fibrosis in chronic kidney disease.
Renal failure
Apr 15, 2025
OBJECTIVE: Kidney fibrosis is a key pathological feature in the progression of chronic kidney disease (CKD), traditionally diagnosed through invasive kidney biopsy. This study aimed to develop and validate a noninvasive, multi-center predictive model...
Root of Prunus persica (taoshugen) ameliorated renal fibrosis by inhibiting TGF-β signaling via upregulating Pmepa1 in mice with unilateral ureter obstruction.
Journal of ethnopharmacology
Apr 3, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Various parts of Prunus persica (L.) Batsch (peach) exhibit medicinal properties and are utilized in traditional Chinese medicine (TCM) for therapeutic purposes. Notably, the root of P. persica, referred to as "taoshug...
Artificial intelligence for predicting interstitial fibrosis and tubular atrophy using diagnostic ultrasound imaging and biomarkers.
BMJ health & care informatics
Mar 17, 2025
BACKGROUND: Chronic kidney disease (CKD) is a global health concern characterised by irreversible renal damage that is often assessed using invasive renal biopsy. Accurate evaluation of interstitial fibrosis and tubular atrophy (IFTA) is crucial for ...
Machine learning selection of basement membrane-associated genes and development of a predictive model for kidney fibrosis.
Scientific reports
Feb 24, 2025
This study investigates the role of basement membrane-related genes in kidney fibrosis, a significant factor in the progression of chronic kidney disease that can lead to end-stage renal failure. The authors aim to develop a predictive model using ma...
Key RNA-binding proteins in renal fibrosis: a comprehensive bioinformatics and machine learning framework for diagnostic and therapeutic insights.
Renal failure
Feb 16, 2025
BACKGROUND: Renal fibrosis is a critical factor in chronic kidney disease progression, with limited diagnostic and therapeutic options. Emerging evidence suggests RNA-binding proteins (RBPs) are pivotal in regulating cellular mechanisms underlying fi...
Machine-learning model based on ultrasomics for non-invasive evaluation of fibrosis in IgA nephropathy.
European radiology
Jan 24, 2025
OBJECTIVES: To develop and validate an ultrasomics-based machine-learning (ML) model for non-invasive assessment of interstitial fibrosis and tubular atrophy (IF/TA) in patients with IgA nephropathy (IgAN).
The Role of Machine Learning in the Detection of Cardiac Fibrosis in Electrocardiograms: Scoping Review.
JMIR cardio
Dec 30, 2024
BACKGROUND: Cardiovascular disease remains the leading cause of mortality worldwide. Cardiac fibrosis impacts the underlying pathophysiology of many cardiovascular diseases by altering structural integrity and impairing electrical conduction. Identif...
Interpretable Deep-learning Model Based on Superb Microvascular Imaging for Noninvasive Diagnosis of Interstitial Fibrosis in Chronic Kidney Disease.
Academic radiology
Dec 16, 2024
RATIONALE AND OBJECTIVES: To develop an interpretable deep learning (XDL) model based on superb microvascular imaging (SMI) for the noninvasive diagnosis of the degree of interstitial fibrosis (IF) in chronic kidney disease (CKD).
Diverse regulated cell death patterns and immune traits in kidney allograft with fibrosis: a prediction of renal allograft failure based on machine learning, single-nucleus RNA sequencing and molecular docking.
Renal failure
Dec 4, 2024
Post-transplant allograft fibrosis remains a challenge in prolonging allograft survival. Regulated cell death has been widely implicated in various kidney diseases, including renal fibrosis. However, the role of different regulated cell death (RCD) ...
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