Hypertrophic cardiomyopathy (HCM), a genetic heart disease defined by unexplained cardiac wall thickening, is a leading cause of sudden death worldwide. However, the three-dimensional organization of cardiac tissue underlying left ventricular hypertr...
Atrial fibrillation (AF), the most common form of cardiac arrhythmia, is closely associated with atrial fibrosis and electrophysiological remodeling, both of which contribute to its persistence and recurrence. Current treatment strategies remain limi...
Current applications of deep learning in renal pathology focused on anatomical structures with morphology, yet little research has focused on the performance of models, such as versatility, in regions with severe kidney damage. In this study, we expl...
BACKGROUND: Neoadjuvant therapy plays an important role in the treatment of glioblastoma (GBM), but a considerable proportion of patients remain unresponsive to the combination of immune checkpoint blockade (ICB) and antiangiogenic therapy. Understan...
BACKGROUND: Severe tubular atrophy/interstitial fibrosis are critical pathological features associated with poor prognosis in IgA nephropathy (IgAN). The early identification of patients at high risk for severe tubular damage could guide clinical man...
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle fiber degeneration and replacement by fibrous and adipose tissues, alongside significant vascular abnormalities. Traditional two-dimensional (2D) histological assessments provid...
Renal fibrosis is a critical pathological process driving chronic kidney disease (CKD) and end-stage renal disease (ESRD). Early diagnosis is essential for timely intervention, yet traditional methods like renal biopsy are invasive and present signif...
Survivors of severe COVID-19 often suffer from long-term respiratory issues, but the molecular drivers of this damage remain unclear. This study explored the dynamics of inflammatory, fibrotic, and endothelial biomarkers in hospitalized COVID-19 pati...
Understanding the process of fibrotic scarring of the myocardium is critical for the diagnosis and risk stratification of life-threatening cardiac dysfunction. Complex changes in structure, composition, and conductivity occurring at different stages ...
BACKGROUND: Diabetic kidney disease (DKD) is the major cause of chronic kidney failure, with tubulointerstitial fibrosis playing a crucial role in disease development. Identifying fibrosis-related genes is crucial for improving diagnosis and developi...
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