AIMC Topic: Fibrosis
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Inflammatory, fibrotic and endothelial biomarker profiles in COVID-19 patients during and following hospitalization.
Scientific reports
Jul 10, 2025
Survivors of severe COVID-19 often suffer from long-term respiratory issues, but the molecular drivers of this damage remain unclear. This study explored the dynamics of inflammatory, fibrotic, and endothelial biomarkers in hospitalized COVID-19 pati...
Multimodal Optical Imaging Combined with Radiomic Analysis for Fibrotic Cardiac Tissue Investigation.
Analytical chemistry
Jul 5, 2025
Understanding the process of fibrotic scarring of the myocardium is critical for the diagnosis and risk stratification of life-threatening cardiac dysfunction. Complex changes in structure, composition, and conductivity occurring at different stages ...
Uncovering key markers and therapeutic targets for renal fibrosis in diabetic kidney disease through bulk and single-cell RNA sequencing.
Journal of translational medicine
Jul 4, 2025
BACKGROUND: Diabetic kidney disease (DKD) is the major cause of chronic kidney failure, with tubulointerstitial fibrosis playing a crucial role in disease development. Identifying fibrosis-related genes is crucial for improving diagnosis and developi...
Identification of potential pathogenic genes associated with the comorbidity of rheumatoid arthritis and renal fibrosis using bioinformatics and machine learning.
Scientific reports
Jul 1, 2025
This study aimed to identify the potential pathogenic genes associated with the comorbidity of rheumatoid arthritis (RA) and renal fibrosis (RF). Transcriptomic data related to RA and RF were retrieved from the GEO database. Differential expression g...
A high-throughput analysis of novel anti-fibrotics in human adult cardiac fibroblasts.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Jun 3, 2025
Myocardial fibrosis, a hallmark of heart failure (HF), contributes to disease progression and mortality by impairing cardiac function. Despite the identification of potential anti-fibrotic molecules, there is a lack of effective pharmacological inter...
Development and validation of multi-center serum creatinine-based models for noninvasive prediction of kidney fibrosis in chronic kidney disease.
Renal failure
Apr 15, 2025
OBJECTIVE: Kidney fibrosis is a key pathological feature in the progression of chronic kidney disease (CKD), traditionally diagnosed through invasive kidney biopsy. This study aimed to develop and validate a noninvasive, multi-center predictive model...
Root of Prunus persica (taoshugen) ameliorated renal fibrosis by inhibiting TGF-β signaling via upregulating Pmepa1 in mice with unilateral ureter obstruction.
Journal of ethnopharmacology
Apr 3, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Various parts of Prunus persica (L.) Batsch (peach) exhibit medicinal properties and are utilized in traditional Chinese medicine (TCM) for therapeutic purposes. Notably, the root of P. persica, referred to as "taoshug...
Artificial intelligence for predicting interstitial fibrosis and tubular atrophy using diagnostic ultrasound imaging and biomarkers.
BMJ health & care informatics
Mar 17, 2025
BACKGROUND: Chronic kidney disease (CKD) is a global health concern characterised by irreversible renal damage that is often assessed using invasive renal biopsy. Accurate evaluation of interstitial fibrosis and tubular atrophy (IFTA) is crucial for ...
Machine learning selection of basement membrane-associated genes and development of a predictive model for kidney fibrosis.
Scientific reports
Feb 24, 2025
This study investigates the role of basement membrane-related genes in kidney fibrosis, a significant factor in the progression of chronic kidney disease that can lead to end-stage renal failure. The authors aim to develop a predictive model using ma...
Key RNA-binding proteins in renal fibrosis: a comprehensive bioinformatics and machine learning framework for diagnostic and therapeutic insights.
Renal failure
Feb 16, 2025
BACKGROUND: Renal fibrosis is a critical factor in chronic kidney disease progression, with limited diagnostic and therapeutic options. Emerging evidence suggests RNA-binding proteins (RBPs) are pivotal in regulating cellular mechanisms underlying fi...
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