An integrated model incorporating deep learning, hand-crafted radiomics and clinical and US features to diagnose central lymph node metastasis in patients with papillary thyroid cancer.

Journal: BMC cancer
PMID:

Abstract

OBJECTIVE: To evaluate the value of an integrated model incorporating deep learning (DL), hand-crafted radiomics and clinical and US imaging features for diagnosing central lymph node metastasis (CLNM) in patients with papillary thyroid cancer (PTC).

Authors

  • Yang Gao
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
  • Weizhen Wang
    Department of Ultrasound, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, Guangdong Province, P. R. China.
  • Yuan Yang
    The Ministry of Education Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Northwestern Polytechnical University, No. 127, Youyi Road (West), Xi'an 710072, China.
  • Ziting Xu
    Department of Ultrasound, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, Guangdong Province, P. R. China.
  • Yue Lin
    Institute of Applied Remote Sensing and Information Technology, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
  • Ting Lang
    Department of Ultrasound, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, Guangdong Province, P. R. China.
  • Shangtong Lei
    Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
  • Yisheng Xiao
    Department of Ultrasound, the First People's Hospital of Foshan, Lingnan Avenue North No.81, Foshan, Guangdong Province, P. R. China.
  • Wei Yang
    Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China. Electronic address: 421063202@qq.com.
  • Weijun Huang
  • Yingjia Li
    Department of Ultrasound, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, Guangdong Province, P. R. China. lyjia@smu.edu.cn.