Simultaneous Determination of Estradiol Cypionate and Medroxyprogesterone Acetate Hormones in Injectable Suspension by UV Spectrophotometry Based on Least-Squares Support Vector Machine and Fuzzy Inference System: Comparison with HPLC.

Journal: Journal of AOAC International
PMID: 37725336

Abstract

BACKGROUND: The combination of estradiol cypionate (ECA) and medroxyprogesterone acetate (MPA) is used to prevent pregnancy in women. The analysis of the ECA and MPA combination reveals a challenge due to the strong overlap of the spectra of these compounds.

Authors

  • Maryam Valizadeh
    Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran.
  • Zahra Ameri Braki
    Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran.
  • Erfan Smiley
    Islamic Azad University, Department of Chemistry, North Tehran Branch, Vafadar Blvd., Shahid Sadoughi St., Hakimiyeh Exit, Shahid Babaee Highway, Tehran 1651153311, Iran.

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