A machine-learning exploration of the exposome from preconception in early childhood atopic eczema, rhinitis and wheeze development.

Journal: Environmental research
PMID:

Abstract

BACKGROUND: Most previous research on the environmental epidemiology of childhood atopic eczema, rhinitis and wheeze is limited in the scope of risk factors studied. Our study adopted a machine learning approach to explore the role of the exposome starting already in the preconception phase.

Authors

  • Yizhi Dong
    Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore. Electronic address: yizhi@nus.edu.sg.
  • Hui Xing Lau
    Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, Singapore, 117609, Singapore. Electronic address: lau_hui_xing@sics.a-star.edu.sg.
  • Noor Hidayatul Aini Suaini
    Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, Singapore, 117609, Singapore. Electronic address: Noor_Hidayatul_Suaini@sics.a-star.edu.sg.
  • Michelle Zhi Ling Kee
    Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, Singapore, 117609, Singapore. Electronic address: Michelle_Kee@sics.a-star.edu.sg.
  • Delicia Shu Qin Ooi
    Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore. Electronic address: paeosqd@nus.edu.sg.
  • Lynette Pei-Chi Shek
    Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: paeshekl@nus.edu.sg.
  • Bee Wah Lee
    Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: paeleebw@nus.edu.sg.
  • Keith M Godfrey
    MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Elizabeth Huiwen Tham
    Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, Singapore, 117609, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore; Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: elizabeth_tham@nuhs.edu.sg.
  • Marcus Eng Hock Ong
    Department of Emergency Medicine, Singapore General Hospital, Singapore, Singapore. marcus.ong.e.h@sgh.com.sg.
  • Nan Liu
    Duke-NUS Medical School Centre for Quantitative Medicine Singapore Singapore.
  • Limsoon Wong
    Department of Computer Science, National University of Singapore, Singapore; Department of Pathology, National University of Singapore, Singapore.
  • Kok Hian Tan
    KK Women's and Children's Hospital, Singapore, Singapore.
  • Jerry Kok Yen Chan
    Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore.
  • Fabian Kok Peng Yap
    Duke-NUS Medical School, National University of Singapore, Singapore; Department of Paediatrics, KK Women's and Children's Hospital (KKH), Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address: fabian.yap.k.p@singhealth.com.sg.
  • Yap Seng Chong
    Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore.
  • Johan Gunnar Eriksson
    Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore.
  • Mengling Feng
    Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore.
  • Evelyn Xiu Ling Loo
    Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, Singapore, 117609, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Dean's Office, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: evelyn_loo@sics.a-star.edu.sg.