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Exposome

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Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960's.

Reproductive toxicology (Elmsford, N.Y.)
Even though the majority of population studies in environmental health focus on a single factor, environmental exposure in the real world is a mixture of many chemicals. The concept of "exposome" leads to an intellectual framework of measuring many e...

A Narrative Literature Review of Natural Language Processing Applied to the Occupational Exposome.

International journal of environmental research and public health
UNLABELLED: The evolution of the Exposome concept revolutionised the research in exposure assessment and epidemiology by introducing the need for a more holistic approach on the exploration of the relationship between the environment and disease. At ...

Supporting the working life exposome: Annotating occupational exposure for enhanced literature search.

PloS one
An individual's likelihood of developing non-communicable diseases is often influenced by the types, intensities and duration of exposures at work. Job exposure matrices provide exposure estimates associated with different occupations. However, due t...

A machine-learning exploration of the exposome from preconception in early childhood atopic eczema, rhinitis and wheeze development.

Environmental research
BACKGROUND: Most previous research on the environmental epidemiology of childhood atopic eczema, rhinitis and wheeze is limited in the scope of risk factors studied. Our study adopted a machine learning approach to explore the role of the exposome st...

Untargeted metabolomics and machine learning unveil the exposome and metabolism linked with the risk of early pregnancy loss.

Journal of hazardous materials
Early pregnancy loss (EPL) may result from exposure to emerging contaminants (ECs), although the underlying mechanisms remain poorly understood. This case-control study measured over 2000 serum features, including 37 ECs, 6 biochemicals, and 2057 end...

An Enhanced Protocol to Expand Human Exposome and Machine Learning-Based Prediction for Methodology Application.

Environmental science & technology
The human exposome remains limited due to the challenging analytical strategies used to reveal low-level endocrine-disrupting chemicals (EDCs) and their metabolites in serum and urine. This limits the integrity of the EDC exposure assessment and hind...