Identification of Panax notoginseng origin using terahertz precision spectroscopy and neural network algorithm.

Journal: Talanta
PMID: 38581849

Abstract

Panax notoginseng (P. notoginseng), a Chinese herb containing various saponins, benefits immune system in medicines development, which from Wenshan (authentic cultivation) is often counterfeited by others for large demand and limited supply. Here, we proposed a method for identifying P. notoginseng origin combining terahertz (THz) precision spectroscopy and neural network. Based on the comparative analysis of four qualitative identification methods, we chose high-performance liquid chromatography (HPLC) and THz spectroscopy to detect 252 samples from five origins. After classifications using Convolutional Neural Networks (CNNs) model, we found that the performance of THz spectra was superior to that of HPLC. The underlying mechanism is that there are clear nonlinear relations among the THz spectra and the origins due to the wide spectra and multi-parameter characteristics, which makes the accuracy of five-classification origin identification up to 97.62%. This study realizes the rapid, non-destructive and accurate identification of P. notoginseng origin, providing a practical reference for herbal medicine.

Authors

  • Hongyu Gu
  • Shengfeng Wang
    University of Shanghai for Science and Technology, Terahertz Technology Innovation Research Institute, Shanghai Key Lab of Modern Optical System, Shanghai Institute of Intelligent Science and Technology, Shanghai, 200093, China.
  • Songyan Hu
    University of Shanghai for Science and Technology, Terahertz Technology Innovation Research Institute, Shanghai Key Lab of Modern Optical System, Shanghai Institute of Intelligent Science and Technology, Shanghai, 200093, China.
  • Xu Wu
    University of Shanghai for Science and Technology, Terahertz Technology Innovation Research Institute, Shanghai Key Lab of Modern Optical System, Shanghai Institute of Intelligent Science and Technology, Shanghai, 200093, China.
  • Qiuye Li
    College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
  • Rongrong Zhang
    Department of Psychiatry Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China.
  • Juan Zhang
    Guangdong R & D Center for Technological Economy RM. 802, Guangzhou, Guangdong, P.R. China.
  • Wenbin Zhang
    Department of Epidemiology and Medical Statistics School of Public Health, Guangdong Medical University, Dongguan, Guangdong, China.
  • Yan Peng
    Key Acu-moxibustion Laboratory of Biological Information Analysis of Institute of Acupuncture, Moxibustion and Massage, Hunan University of Chinese Medicine, Changsha 410007, China.

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