Automated Detection and Grading of Extraprostatic Extension of Prostate Cancer at MRI via Cascaded Deep Learning and Random Forest Classification.

Journal: Academic radiology
PMID: 38670874

Abstract

RATIONALE AND OBJECTIVES: Extraprostatic extension (EPE) is well established as a significant predictor of prostate cancer aggression and recurrence. Accurate EPE assessment prior to radical prostatectomy can impact surgical approach. We aimed to utilize a deep learning-based AI workflow for automated EPE grading from prostate T2W MRI, ADC map, and High B DWI.

Authors

  • Benjamin D Simon
    Molecular Imaging Branch, NCI, NIH, Bethesda, Maryland, USA (B.D.S., K.M.M., S.A.H., E.C.Y., P.L.C., B.T.); Institute of Biomedical Engineering, Department Engineering Science, University of Oxford, UK (B.D.S.).
  • Katie M Merriman
    Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
  • Stephanie A Harmon
    Clinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland, USA.
  • Jesse Tetreault
    NVIDIA Corporation, Bethesda, Maryland, USA.
  • Enis C Yilmaz
    Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Zoë Blake
    Urology Oncology Branch, NCI, NIH, Bethesda, Maryland, USA (Z.B., S.G., P.A.P.).
  • Maria J Merino
    Center for Interventional Oncology, National Cancer Institute & Clinical Center, National Institutes of Health, Bethesda, MD, USA.
  • Julie Y An
    Department of Radiology, University of California, San Diego, California, USA (J.Y.A.).
  • Jamie Marko
    Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD.
  • Yan Mee Law
    Department of Diagnostic Radiology, Singapore General Hospital, Singapore.
  • Sandeep Gurram
    National Cancer Institute, Bethesda, MD.
  • Bradford J Wood
    Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Peter L Choyke
    Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Peter A Pinto
    Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Baris Turkbey
    Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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