VENet: Variational energy network for gland segmentation of pathological images and early gastric cancer diagnosis of whole slide images.

Journal: Computer methods and programs in biomedicine
Published Date:

Abstract

BACKGROUND AND OBJECTIVE: Gland segmentation of pathological images is an essential but challenging step for adenocarcinoma diagnosis. Although deep learning methods have recently made tremendous progress in gland segmentation, they have not given satisfactory boundary and region segmentation results of adjacent glands. These glands usually have a large difference in glandular appearance, and the statistical distribution between the training and test sets in deep learning is inconsistent. These problems make networks not generalize well in the test dataset, bringing difficulties to gland segmentation and early cancer diagnosis.

Authors

  • Shuchang Zhang
    Department of Mathematics, National University of Defense Technology, Changsha, China. Electronic address: zhangshuchang19@163.com.
  • Ziyang Yuan
    Department of Mathematics, National University of Defense Technology, Changsha, China. Electronic address: yuanziyang11@nudt.edu.cn.
  • Xianchen Zhou
    Department of Mathematics, National University of Defense Technology, Changsha, China.
  • Hongxia Wang
    Department of Mathematics, National University of Defense Technology, Changsha, China. Electronic address: wanghongxia@nudt.edu.cn.
  • Bo Chen
  • Yadong Wang
    The Biofoundry, Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States.