Large-Vessel Vasculopathy in Children With Sickle Cell Disease: A Magnetic Resonance Imaging Study of Infarct Topography and Focal Atrophy.

Journal: Pediatric neurology
Published Date:

Abstract

BACKGROUND: Large-vessel vasculopathy (LVV) increases stroke risk in pediatric sickle cell disease beyond the baseline elevated stroke risk in this vulnerable population. The mechanisms underlying this added risk and its unique impact on the developing brain are not established.

Authors

  • Kristin P Guilliams
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri; Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri.
  • Melanie E Fields
    Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri.
  • Dustin K Ragan
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri.
  • Yasheng Chen
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri.
  • Cihat Eldeniz
    Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri.
  • Monica L Hulbert
    Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri.
  • Michael M Binkley
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri.
  • James N Rhodes
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri.
  • Joshua S Shimony
    Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri; Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri.
  • Robert C McKinstry
    Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri; Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri.
  • Katie D Vo
    Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri.
  • Hongyu An
    Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri.
  • Jin-Moo Lee
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri; Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri. Electronic address: leejm@wustl.edu.
  • Andria L Ford
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri. Electronic address: forda@wustl.edu.