Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN.

Journal: Oncotarget
PMID:

Abstract

PURPOSE: Sequential PET/CT studies oncology patients can undergo during their treatment follow-up course is limited by radiation dosage. We propose an artificial intelligence (AI) tool to produce attenuation-corrected PET (AC-PET) images from non-attenuation-corrected PET (NAC-PET) images to reduce need for low-dose CT scans.

Authors

  • Kevin C Ma
    Artificial Intelligence Resource, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Esther Mena
    Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr., MSC 1182, Building 10, Room B3B85, Bethesda, Maryland, USA (M.J.B., S.A.H., N.S.L., E.C.Y., T.E.P., B.S., L.L., E.M., P.L.C., B.T.).
  • Liza Lindenberg
    Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr., MSC 1182, Building 10, Room B3B85, Bethesda, Maryland, USA (M.J.B., S.A.H., N.S.L., E.C.Y., T.E.P., B.S., L.L., E.M., P.L.C., B.T.).
  • Nathan S Lay
    Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr., MSC 1182, Building 10, Room B3B85, Bethesda, Maryland.
  • Phillip Eclarinal
    Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Deborah E Citrin
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
  • Peter A Pinto
    Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Bradford J Wood
    Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • William L Dahut
    Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA (W.L.D., R.A.M.).
  • James L Gulley
    Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Ravi A Madan
    Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA (W.L.D., R.A.M.).
  • Peter L Choyke
    Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Ismail Baris Turkbey
    Artificial Intelligence Resource, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Stephanie A Harmon
    Clinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland, USA.