Multimodal radiotherapy dose prediction using a multi-task deep learning model.

Journal: Medical physics
Published Date:

Abstract

BACKGROUND: In radiation therapy (RT), accelerated partial breast irradiation (APBI) has emerged as an increasingly preferred treatment modality over conventional whole breast irradiation due to its targeted dose delivery and shorter course of treatment. APBI can be delivered through various modalities including Cobalt-60-based systems and linear accelerators with C-arm, O-ring, or robotic arm design. Each modality possesses distinct features, such as beam energy or the degrees of freedom in treatment planning, which influence their respective dose distributions. These modality-specific considerations emphasize the need for a quantitative approach in determining the optimal dose delivery modality on a patient-specific basis. However, manually generating treatment plans for each modality across every patient is time-consuming and clinically impractical.

Authors

  • Austen Maniscalco
    Medical Artificial Intelligence and Automation Laboratory, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Ezek Mathew
    Medical Artificial Intelligence and Automation Laboratory, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • David Parsons
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: david.parsons@utsouthwestern.edu.
  • Justin Visak
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Mona Arbab
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Prasanna Alluri
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Xingzhe Li
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Narine Wandrey
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Mu-Han Lin
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Asal Rahimi
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Steve Jiang
  • Dan Nguyen
    University of Massachusetts Chan Medical School, Worcester, Massachusetts.