Development of an immunoinflammatory indicator-related dynamic nomogram based on machine learning for the prediction of intravenous immunoglobulin-resistant Kawasaki disease patients.

Journal: International immunopharmacology
PMID:

Abstract

BACKGROUND: Approximately 10-20% of Kawasaki disease (KD) patients suffer from intravenous immunoglobulin (IVIG) resistance, placing them at higher risk of developing coronary artery aneurysms. Therefore, we aimed to construct an IVIG resistance prediction tool for children with KD in Shanghai, China.

Authors

  • Yue Wang
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
  • Yinyin Cao
    Cardiovascular Center, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China. Electronic address: yinyin19881126@126.com.
  • Yang Li
    Occupation of Chinese Center for Disease Control and Prevention, Beijing, China.
  • Fenhua Zhu
    Clinical Laboratory Center, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China. Electronic address: gzffdek399@sina.com.
  • Meifen Yuan
    Clinical Laboratory Center, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China. Electronic address: ymf19881126@126.com.
  • Jin Xu
    Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE, and School of Statistics, East China Normal University, Shanghai, China.
  • Xiaojing Ma
    Robert F. Smith School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA.
  • Jian Li
    Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, China.