Evaluation of machine learning-based classification of clinical impairment and prediction of clinical worsening in multiple sclerosis.

Journal: Journal of neurology
PMID:

Abstract

BACKGROUND: Robust predictive models of clinical impairment and worsening in multiple sclerosis (MS) are needed to identify patients at risk and optimize treatment strategies.

Authors

  • Samantha Noteboom
    MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands. s.noteboom@amsterdamumc.nl.
  • Moritz Seiler
    Charité - Universitätsmedizin Berlin, Corporate Member Of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Psychiatry and Psychotherapy, 10117 Berlin, Germany; Bernstein Center for Computational Neuroscience, 10117 Berlin, Germany.
  • Claudia Chien
    Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Roshan P Rane
    Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Frederik Barkhof
    MS Center Amsterdam, Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
  • Eva M M Strijbis
    MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
  • Friedemann Paul
    Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Department of Neurology, 10117 Berlin, Germany; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), NeuroCure Clinical Research Center, 10117 Berlin, Germany; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universitt zu Berlin, Berlin Institute of Health (BIH), Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine, 10117 Berlin, Germany; Einstein Center for Digital Future Berlin, Germany.
  • Menno M Schoonheim
    MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.
  • Kerstin Ritter
    Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Department of Psychiatry and Psychotherapy, 10117 Berlin, Germany; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health (BIH), Berlin Center for Advanced Neuroimaging, Bernstein Center for Computational Neuroscience, 10117 Berlin, Germany. Electronic address: kerstin.ritter@charite.de.