Prediction of Interactomic HUB Genes in Periodontitis With Acute Myocardial Infarction.

Journal: The Journal of craniofacial surgery
PMID: 38829148

Abstract

BACKGROUND: Acute myocardial infarction (AMI) risk correlates with C-reactive protein (CRP) levels, suggesting systemic inflammation is present well before AMI. Studying different types of periodontal disease (PD), extremely common in individuals at risk for AMI, has been one important research topic. According to recent research, AMI and PD interact via the systemic production of certain proinflammatory and anti-inflammatory cytokines, small signal molecules, and enzymes that control the onset and development of both disorders' chronic inflammatory reactions. This study uses machine learning to identify the interactome hub biomarker genes in acute myocardial infarction and periodontitis.

Authors

  • Sri Sivashankari Thilagar
    Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
  • Pradeep Kumar Yadalam
    Department of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and Technology Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India.
  • Vincenzo Ronsivalle
    Department of Orthodontics, School of Dentistry, University of Catania, Catania, Italy.
  • Marco Cicciù
    Department of Biomedical and Surgical and Biomedical Sciences, Catania University, 95123, Catania, CT, Italy.
  • Giuseppe Minervini
    Saveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai, India. Giuseppe.minervini@unicampania.it.

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