Unraveling the complexity of the senescence-associated secretory phenotype in adamantinomatous craniopharyngioma using multimodal machine learning analysis.

Journal: Neuro-oncology
PMID: 38334125

Abstract

BACKGROUND: Cellular senescence can have positive and negative effects on the body, including aiding in damage repair and facilitating tumor growth. Adamantinomatous craniopharyngioma (ACP), the most common pediatric sellar/suprasellar brain tumor, poses significant treatment challenges. Recent studies suggest that senescent cells in ACP tumors may contribute to tumor growth and invasion by releasing a senesecence-associated secretory phenotype. However, a detailed analysis of these characteristics has yet to be completed.

Authors

  • Eric W Prince
    Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO, United States.
  • John R Apps
    Oncology Department, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • John Jeang
    Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.
  • Keanu Chee
    Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Stephen Medlin
    Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Eric M Jackson
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, 21205, USA.
  • Roy Dudley
    Department of Neurosurgery, McGill University, Montreal, H3A 2B4, Canada.
  • David Limbrick
    Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Robert Naftel
    Department of Neurological Surgery, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, 37212, USA.
  • James Johnston
    Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.
  • Neil Feldstein
    Department of Neurosurgery, Columbia University Medical Center, New York, New York, USA.
  • Laura M Prolo
    Department of Neurosurgery, Stanford University, Stanford, CA, USA.
  • Kevin Ginn
    Division of Pediatric Hematology and Oncology, Children's Mercy Hospital, Kansas City, 64108, USA.
  • Toba Niazi
    Department of Pediatric Neurosurgery, Nicklaus Children's Hospital, Miami, Florida, USA.
  • Amy Smith
    Department of Pediatric Hematology-Oncology, Arnold Palmer Hospital, Orlando, 32806, USA.
  • Lindsay Kilburn
    Children's National Health System, Brain Tumor Institute, Washington, DC, 20010, USA.
  • Joshua Chern
    2Department of Neurosurgery, Children's Healthcare of Atlanta, Georgia.
  • Jeffrey Leonard
    Division of Pediatric Neurosurgery, Nationwide Children's Hospital, Columbus, Ohio, USA.
  • Sandi Lam
    Division of Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
  • David S Hersh
    Departments of7Surgery and.
  • Jose Mario Gonzalez-Meljem
    U. Tecnologico de Monterrey, School of Engineering and Sciences, Mexico City, Mexico.
  • Vladimir Amani
    Morgan Adams Foundation for Pediatric Brain Tumor Research Program, Aurora, Colorado, USA.
  • Andrew M Donson
    Morgan Adams Foundation Pediatric Brain Tumor Research Program, Aurora, 80045, USA.
  • Siddhartha S Mitra
    Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
  • Pratiti Bandopadhayay
    Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.
  • Juan Pedro Martinez-Barbera
    Developmental Biology and Cancer, Birth Defects Research Centre, GOS Institute of Child Health, University College London, London, UK.
  • Todd C Hankinson
    Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO, United States.

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