Explainable machine learning models for early gastric cancer diagnosis.

Journal: Scientific reports
Published Date:

Abstract

Gastric cancer remains a significant global health concern, with a notably high incidence in East Asia. This paper explores the potential of explainable machine learning models in enhancing the early diagnosis of gastric cancer. Through comprehensive evaluations, various machine learning models, including WeightedEnsemble, CatBoost, and RandomForest, demonstrated high potential in accurately diagnosing early gastric cancer. The study emphasizes the importance of model explainability in medical diagnostics, showing how transparent, explainable models can increase trust and clinical acceptance, thereby improving diagnostic accuracy and patient outcomes. This research not only highlights key biomarkers and clinical features critical for early detection but also presents a versatile approach that could be applied to other medical diagnostics, promoting broader adoption of machine learning in clinical settings.

Authors

  • Hongyang Du
    Heze Administrative Approval Guarantee Center, 3443 Huanghe East Road, Heze City, 274000, Shandong Province, China.
  • Qingfen Yang
    Heze Municipal Hospital, 2888 Caozhou West Road, Heze City, 274031, Shandong Province, China.
  • Aimin Ge
    Heze Municipal Hospital, 2888 Caozhou West Road, Heze City, 274031, Shandong Province, China.
  • Chenhao Zhao
    Heze Municipal Hospital, 2888 Caozhou West Road, Heze City, 274031, Shandong Province, China.
  • Yunhua Ma
    Heze Municipal Hospital, 2888 Caozhou West Road, Heze City, 274031, Shandong Province, China.
  • Shuyu Wang
    Department of Control Engineering, Northeastern University, Qinhuangdao, Hebei, 066001, PR China. Electronic address: wangshuyu@neuq.edu.cn.