Frontiers in pharmacology
Feb 3, 2025
INTRODUCTION: Traditional drug discovery efforts primarily target rapid, reversible protein-mediated adaptations to counteract cancer cell resistance. However, cancer cells also utilize DNA-based strategies, often perceived as slow, irreversible chan...
Frontiers in pharmacology
Jan 24, 2025
INTRODUCTION: Steroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating condition with no specific treatment. Inhibiting osteocyte apoptosis may be a promising therapeutic approach. Shengxue Busui Decoction (SBD) has shown protectiv...
Frontiers in pharmacology
Jan 13, 2025
BACKGROUND: Lower-grade glioma (LGG) exhibits significant heterogeneity in clinical outcomes, and current prognostic markers have limited predictive value. Despite the growing recognition of histone modifications in tumor progression, their role in L...
Frontiers in pharmacology
Jan 10, 2025
INTRODUCTION: This study evaluated the relationship between total plasma and free kidney concentrations of amphotericin B (AmB) in healthy and -infected Wistar rats using microdialysis and has the potential to significantly impact future research in ...
Frontiers in pharmacology
Jan 9, 2025
BACKGROUND: Dabigatran etexilate (DABE), a prodrug of dabigatran (DAB), is a direct thrombin inhibitor used to prevent ischemic stroke and thromboembolism during atrial fibrillation. The effect of genetic polymorphisms on its metabolism, particularly...
Frontiers in pharmacology
Jan 9, 2025
BACKGROUND: Pancreatic cancer remains one of the deadliest malignancies, largely due to its late diagnosis and lack of effective therapeutic targets.
Frontiers in pharmacology
Jan 8, 2025
Natural pigments, or natural colorants, are frequently utilized in the food industry due to their diverse functional and nutritional attributes. Beyond their color properties, these pigments possess several biological activities, including antioxidan...
Frontiers in pharmacology
Jan 7, 2025
INTRODUCTION: Lipopolysaccharide (LPS), a constituent of the outer membrane of Gram-negative bacteria, is a powerful inducer of systemic inflammation and has been extensively utilized in experimental models to simulate inflammatory responses and sept...
Frontiers in pharmacology
Jan 7, 2025
OBJECTIVE: This study aims to evaluate the association between the white blood cell-to-platelet ratio (WPR) and 28-day all-cause mortality among patients experiencing cardiac arrest.
Frontiers in pharmacology
Jan 7, 2025
INTRODUCTION: The L. (PVL) and Hand.-Mazz. (TH) herb pair, which is commonly used in traditional Chinese medicine (TCM), has been applied for the treatment of breast cancer. Although its efficacy is validated, the synergistic anti-breast cancer com...