AIMC Topic: Aldehyde Dehydrogenase 1 Family
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Modeling 5-FU-Induced Chemotherapy Selection of a Drug-Resistant Cancer Stem Cell Subpopulation.
Current oncology (Toronto, Ont.)
Feb 25, 2024
(1) Background: Cancer stem cells (CSCs) are a subpopulation of cells in a tumor that can self-regenerate and produce different types of cells with the ability to initiate tumor growth and dissemination. Chemotherapy resistance, caused by numerous me...
Multiple machine learning models combined with virtual screening and molecular docking to identify selective human ALDH1A1 inhibitors.
Journal of molecular graphics & modelling
May 28, 2021
Aldehyde dehydrogenases (ALDHs) are the enzymes of oxidoreductase family that are responsible for the aldehyde metabolism. The unbalanced expression of these enzymes may be associated with a variety of disease conditions including cancers. ALDH1A1 is...
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