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Integrating DNA structure switch with branched hairpins for the detection of uracil-DNA glycosylase activity and inhibitor screening.

Talanta 29310268
The detection of uracil-DNA glycosylase (UDG) activity is pivotal for its biochemical studies and the development of drugs for UDG-related diseases. Here, we explored an integrated DNA structure switch for high sensitive detection of UDG activity. Th...
Base Pairing Benzothiazoles DNA Enzyme Inhibitors Fluorescent Dyes G-Quadruplexes HeLa Cells High-Throughput Screening Assays Humans Inverted Repeat Sequences Limit of Detection MCF-7 Cells Oligonucleotides Spectrometry, Fluorescence Thiazoles Uracil-DNA Glycosidase
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