Journal of computer-aided molecular design
Nov 4, 2025
Antimicrobial resistance (AMR) remains a global health crisis, necessitating the development of novel therapeutics against multidrug-resistant pathogens. In this study, ten (10) hybrid imine-benzalacetophenone derivatives (7a-7j), incorporating pyrid...
Journal of computer-aided molecular design
Nov 4, 2025
Mycobacterium tuberculosis (Mtb) continues to be one of the major contributors to the global burden of infectious diseases. Many drugs used in the current treatment regime have fallen prey to the puzzling phenomenon of antimicrobial resistance. Despi...
OBJECTIVES: Rapid discrimination of infections caused by (MTB) and non-tuberculous mycobacteria (NTM) is crucial in clinical settings. Despite overlapping clinical and radiological features, the two require markedly different therapeutic approaches ...
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global public health threat. The rising prevalence of HIV/TB co-infection and multidrug-resistant tuberculosis (MDR-TB) has further intensified this challenge. This study ...
Deutsche medizinische Wochenschrift (1946)
Sep 29, 2025
Tuberculosis remains the leading cause of death by a single infectious agent worldwide, with over 10 million cases annually. Despite global efforts, delayed or missed diagnoses continue to fuel transmission and mortality, particularly in resource-lim...
With human guidance, computers now use machine learning (ML) in artificial intelligence (AI) to learn from data, detect trends, and make predictions. Software can adapt and improve with new information. Imaging scans leverage pattern recognition to p...
BACKGROUND: Mycobacterium tuberculosis (MTB) is a human-specific pathogen that primarily infects humans, causing tuberculosis (TB). Antimicrobial resistance (AMR) in MTB presents a formidable challenge to global health. The employment of machine lear...
INTRODUCTION: Early and accurate diagnosis of tuberculosis (TB) is central to ensuring the proper treatment and curbing the transmission of the disease. Despite the significant burden, the diagnosis of peripheral lymph node(LN)TB, the most prevalent ...
Tuberculosis, a deadly and contagious disease caused by Mycobacterium tuberculosis, remains a significant global public health threat. HIV co-infection significantly increases the risk of active TB recurrence and prolongs medical treatment for tuberc...
New solutions are needed to detect genotype-phenotype associations involved in microbial drug resistance. Herein, we describe a Group Association Model (GAM) that accurately identifies genetic variants linked to drug resistance and mitigates false-po...
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