AIMC Topic: Mycobacterium tuberculosis
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Assessing the performance of a point-of-need diagnostic algorithm in rapid detection of peripheral lymph node tuberculosis (Mobile-TB-Lab): a diagnostic evaluation study protocol.
BMJ open
May 30, 2025
INTRODUCTION: Early and accurate diagnosis of tuberculosis (TB) is central to ensuring the proper treatment and curbing the transmission of the disease. Despite the significant burden, the diagnosis of peripheral lymph node(LN)TB, the most prevalent ...
A comparative study on TB incidence and HIVTB coinfection using machine learning models on WHO global TB dataset.
Scientific reports
Apr 21, 2025
Tuberculosis, a deadly and contagious disease caused by Mycobacterium tuberculosis, remains a significant global public health threat. HIV co-infection significantly increases the risk of active TB recurrence and prolongs medical treatment for tuberc...
Enhanced diagnosis of multi-drug-resistant microbes using group association modeling and machine learning.
Nature communications
Mar 25, 2025
New solutions are needed to detect genotype-phenotype associations involved in microbial drug resistance. Herein, we describe a Group Association Model (GAM) that accurately identifies genetic variants linked to drug resistance and mitigates false-po...
Multimodal machine learning-based model for differentiating nontuberculous mycobacteria from .
Frontiers in public health
Feb 17, 2025
OBJECTIVE: To develop and evaluate the effectiveness of multimodal machine learning approach for the differentiation of NTM from MTB.
Artificial Intuition and accelerating the process of antimicrobial drug discovery.
Computers in biology and medicine
Feb 14, 2025
New drug development is a very challenging, expensive, and usually time-consuming process. This issue is very important with regard to antimicrobials, which are affected by the global issue of the development and spread of resistance. This framework ...
Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms in .
Proceedings of the National Academy of Sciences of the United States of America
Feb 6, 2025
Tuberculosis (TB), caused by , remains a significant global health threat, affecting an estimated 10.6 million people in 2022. The emergence of multidrug resistant and extensively drug resistant strains necessitates the development of novel and effec...
Hyb_SEnc: An Antituberculosis Peptide Predictor Based on a Hybrid Feature Vector and Stacked Ensemble Learning.
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Tuberculosis has plagued mankind since ancient times, and the struggle between humans and tuberculosis continues. Mycobacterium tuberculosis is the leading cause of tuberculosis, infecting nearly one-third of the world's population. The rise of pepti...
Machine learning-based prediction of antibiotic resistance in Mycobacterium tuberculosis clinical isolates from Uganda.
BMC infectious diseases
Dec 5, 2024
BACKGROUND: Efforts toward tuberculosis management and control are challenged by the emergence of Mycobacterium tuberculosis (MTB) resistance to existing anti-TB drugs. This study aimed to explore the potential of machine learning algorithms in predi...
Female
Young Adult
Adult
Microbial Sensitivity Tests
Uganda
Male
Middle Aged
Humans
Machine Learning
Drug Resistance, Bacterial
Rifampin
Streptomycin
Polymorphism, Single Nucleotide
Mycobacterium tuberculosis
Tuberculosis, Multidrug-Resistant
Antitubercular Agents
Isoniazid
Whole Genome Sequencing
South Africa
Integrated machine learning and physics-based methods assisted de novo design of Fatty Acyl-CoA synthase inhibitors.
Expert opinion on drug discovery
Nov 25, 2024
BACKGROUND: Tuberculosis is an infectious disease that has become endemic worldwide. The causative bacteria (Mtb) is targeted via several exciting drug targets. One newly discovered target is the Fatty Acyl-CoA synthase, which plays a significant ro...
Small Molecule Inhibitors of Topoisomerase I Identified by Machine Learning and In Vitro Assays.
International journal of molecular sciences
Nov 15, 2024
Tuberculosis (TB) caused by is a leading infectious cause of death globally. The treatment of patients becomes much more difficult for the increasingly common multi-drug resistant TB. Topoisomerase I is essential for the viability of and has been v...
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