AIMC Topic: Burkholderia cepacia

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Enhancement of protein thermostability by three consecutive mutations using loop-walking method and machine learning.

Scientific reports Jun 4, 2021
We developed a method to improve protein thermostability, "loop-walking method". Three consecutive positions in 12 loops of Burkholderia cepacia lipase were subjected to random mutagenesis to make 12 libraries. Screening allowed us to identify L7 as ...
Machine Learning Computational Biology Escherichia coli Proteins Mutation Kinetics Molecular Dynamics Simulation Enzyme Stability Plasmids Lipase Polymerase Chain Reaction Molecular Conformation Hot Temperature Mutagenesis Hydrolases Mutagenesis, Site-Directed Protein Engineering Burkholderia cepacia
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