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G-Protein-Coupled Receptor Kinase 5

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Unveiling G-protein coupled receptor kinase-5 inhibitors for chronic degenerative diseases: Multilayered prioritization employing explainable machine learning-driven multi-class QSAR, ligand-based pharmacophore and free energy-inspired molecular simulation.

International journal of biological macromolecules 38697440
GRK5 holds a pivotal role in cellular signaling pathways, with its overexpression in cardiomyocytes, neuronal cells, and tumor cells strongly associated with various chronic degenerative diseases, which highlights the urgent need for potential inhibi...
Binding Sites Chronic Disease G-Protein-Coupled Receptor Kinase 5 Humans Ligands Machine Learning Molecular Docking Simulation Molecular Dynamics Simulation Pharmacophore Protein Binding Protein Kinase Inhibitors Quantitative Structure-Activity Relationship Thermodynamics
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