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Nucleoside-Phosphate Kinase

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Enhancement of Nucleoside Production in Based on Biosynthetic Pathway Analysis.

BioMed research international 29333435
To enhance nucleoside production in , the biosynthetic pathways of purine and pyrimidine nucleosides were constructed and verified. The differential expression analysis showed that , and genes involved in purine nucleotide biosynthesis were signifi...
Biosynthetic Pathways Carbon-Nitrogen Ligases Hypocreales Nucleoside-Phosphate Kinase Nucleosides Purines Pyrimidines Uridine
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Machine learning-based drug design for identification of thymidylate kinase inhibitors as a potential anti-Mycobacterium tuberculosis.

Journal of biomolecular structure & dynamics 37232453
The rise of antibiotic-resistant Mycobacterium tuberculosis (Mtb) has reduced the availability of medications for tuberculosis therapy, resulting in increased morbidity and mortality globally. Tuberculosis spreads from the lungs to other parts of the...
Algorithms Antitubercular Agents Drug Design Humans Machine Learning Molecular Docking Simulation Molecular Dynamics Simulation Mycobacterium tuberculosis Nucleoside-Phosphate Kinase Protein Binding Protein Kinase Inhibitors
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Cheminformatics and machine learning approaches for repurposing anti-viral compounds against monkeypox virus thymidylate kinase.

Molecular diversity 37531040
One of the emerging epidemic concerns is Monkeypox disease which is spreading globally. This disease is caused by the monkeypox virus (MPXV), with an increasing global incidence with an outbreak in 2022. One of the novel targets for monkeypox disease...
Antiviral Agents Cheminformatics Drug Repositioning Machine Learning Molecular Docking Simulation Molecular Dynamics Simulation Nucleoside-Phosphate Kinase
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Identification of mycobacterial Thymidylate kinase inhibitors: a comprehensive pharmacophore, machine learning, molecular docking, and molecular dynamics simulation studies.

Molecular diversity 39152354
Thymidylate kinase (TMK) is a pivotal enzyme in Mycobacterium tuberculosis (Mtb), crucial for phosphorylating thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), thereby playing a critical role in DNA biosynthesis. Dysregulation or inhibi...
Antitubercular Agents Enzyme Inhibitors Machine Learning Molecular Docking Simulation Molecular Dynamics Simulation Mycobacterium tuberculosis Nucleoside-Phosphate Kinase Pharmacophore Protein Binding Protein Kinase Inhibitors
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