AIMC Topic: Phosphatidylinositols
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Cryptic mutations of PLC family members in brain disorders: recent discoveries and a deep-learning-based approach.
Brain : a journal of neurology
Apr 19, 2023
Phospholipase C (PLC) is an essential isozyme involved in the phosphoinositide signalling pathway, which maintains cellular homeostasis. Gain- and loss-of-function mutations in PLC affect enzymatic activity and are therefore associated with several d...
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