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Phosphoinositide Phospholipase C

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Prediction of genetic alteration of phospholipase C isozymes in brain disorders: Studies with deep learning.

Advances in biological regulation
Genetic mutations leading to the development of various diseases, such as cancer, diabetes, and neurodegenerative disorders, can be attributed to multiple mechanisms and exposure to diverse environments. These disorders further increase gene mutation...

Cryptic mutations of PLC family members in brain disorders: recent discoveries and a deep-learning-based approach.

Brain : a journal of neurology
Phospholipase C (PLC) is an essential isozyme involved in the phosphoinositide signalling pathway, which maintains cellular homeostasis. Gain- and loss-of-function mutations in PLC affect enzymatic activity and are therefore associated with several d...