AIMC Topic: Receptors, Thyroid Hormone

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An in silico to in vivo approach identifies retinoid-X receptor activating tert-butylphenols used in food contact materials.

Scientific reports Jul 18, 2025
The potential for food contact chemicals to disrupt genetic programs in development and metabolism raises concerns. Nuclear receptors (NRs) control many of these programs, and the retinoid-X receptor (RXR) is a DNA-binding partner for one-third of th...
Humans Machine Learning Computer Simulation Animals Protein Binding Signal Transduction Phenols Models, Molecular Xenopus laevis Retinoid X Receptors Receptors, Thyroid Hormone
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Classification of thyroid hormone receptor agonists and antagonists using statistical learning approaches.

Molecular diversity Jul 16, 2018
In silico models are presented for modeling and predicting thyroid hormone receptor (TR) agonists and antagonists. A data set consisting of 258 compounds is used in the present work. The C4.5, random forest (RF) and support vector machine (SVM) stati...
Algorithms Drug Discovery Support Vector Machine Ligands Quantitative Structure-Activity Relationship Receptors, Thyroid Hormone
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