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Schistosomicides

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Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence.

Frontiers in immunology
Schistosomiasis is a parasitic disease caused by trematode worms of the genus and affects over 200 million people worldwide. The control and treatment of this neglected tropical disease is based on a single drug, praziquantel, which raises concerns ...

GNN-DDAS: Drug discovery for identifying anti-schistosome small molecules based on graph neural network.

Journal of computational chemistry
Schistosomiasis is a tropical disease that poses a significant risk to hundreds of millions of people, yet often goes unnoticed. While praziquantel, a widely used anti-schistosome drug, has a low cost and a high cure rate, it has several drawbacks. T...