A machine learning model to predict liver-related outcomes after the functional cure of chronic hepatitis B.

Journal: Journal of hepatology
PMID:

Abstract

BACKGROUND & AIMS: The risk of hepatocellular carcinoma (HCC) and hepatic decompensation persists after hepatitis B surface antigen (HBsAg) seroclearance. This study aimed to develop and validate a machine learning model to predict the risk of liver-related outcomes (LROs) following HBsAg seroclearance.

Authors

  • Moon Haeng Hur
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • Terry Cheuk-Fung Yip
    Medical Data Analytics Center, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Seung Up Kim
    Department of Internal Medicine and Yonsei Liver Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Hyun Woong Lee
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Han Ah Lee
    Department of Internal Medicine, Korea University Anam Hospital, Korea University College, Republic of Korea; Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.
  • Hyung-Chul Lee
    From the Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
  • Grace Lai-Hung Wong
    Medical Data Analytics Center, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Vincent Wai-Sun Wong
    Medical Data Analytics Center, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Jun Yong Park
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Sang Hoon Ahn
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
  • Beom Kyung Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • Hwi Young Kim
    Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
  • Yeon Seok Seo
    Department of Internal Medicine, Korea University Anam Hospital, Korea University College, Republic of Korea.
  • Hyunjae Shin
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • Jeayeon Park
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • Yunmi Ko
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • Youngsu Park
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • Yun Bin Lee
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Su Jong Yu
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  • Sang Hyub Lee
    Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.
  • Yoon Jun Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Jung-Hwan Yoon
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Jeong-Hoon Lee