AIMC Topic: Hepatitis B Surface Antigens
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Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy.
Scientific reports
May 9, 2025
Medical interns are at high risk of acquiring Hepatitis B Virus (HBV) infection during their training. HBV vaccination is the most effective measure to reduce the global incidence of HBV. The duration of protection after HBV vaccination is still cont...
A machine learning model to predict liver-related outcomes after the functional cure of chronic hepatitis B.
Journal of hepatology
Aug 31, 2024
BACKGROUND & AIMS: The risk of hepatocellular carcinoma (HCC) and hepatic decompensation persists after hepatitis B surface antigen (HBsAg) seroclearance. This study aimed to develop and validate a machine learning model to predict the risk of liver-...
Neural Network Enables High Accuracy for Hepatitis B Surface Antigen Detection with a Plasmonic Platform.
Nano letters
Jul 8, 2024
The detection of hepatitis B surface antigen (HBsAg) is critical in diagnosing hepatitis B virus (HBV) infection. However, existing clinical detection technologies inevitably cause certain inaccuracies, leading to delayed or unwarranted treatment. He...
Clinical cure induced by pegylated interferon α-2b in the advantaged population of chronic hepatitis B virus infection: a retrospective cohort study.
Frontiers in cellular and infection microbiology
Jan 16, 2024
BACKGROUND: Among the advantaged population with clinical cure of chronic hepatitis B, chronic inactive hepatitis B virus carriers (IHCs) and nucleoside analog-experienced patients have similar serological manifestations. This study established non-i...
Serological and Molecular Characterization of Occult HBV Infection in Blood Donors from South Italy.
Viruses
Dec 31, 2023
Despite good vaccine coverage and careful blood donor selection policies, hepatitis B virus (HBV) is still the most frequent viral infection among blood donors (BDs) in Italy, mostly in the occult form (OBI). We studied the virological features of OB...
The role of quantitative HBsAg in the natural history of e antigen-negative chronic hepatitis B: A Tunisian prospective study.
Infectious diseases now
Dec 30, 2020
BACKGROUND/AIMS: During the natural course of Chronic Hepatitis B (CHB) infection, differentiation between inactive carrier (IC) and HBeAg negative CHB is a subject of ongoing debate. We studied the role of hepatitis B surface antigen (HBsAg) level a...
Accurate and cost-effective prediction of HBsAg titer in industrial scale fermentation process of recombinant Pichia pastoris by using neural network based soft sensor.
Biotechnology and applied biochemistry
Jun 24, 2019
In the current work, the attempt was made to apply best-fitted artificial neural network (ANN) architecture and the respective training process for predicting final titer of hepatitis B surface antigen (HBsAg), produced intracellularly by recombinant...
Using Machine Learning Algorithms to Predict Hepatitis B Surface Antigen Seroclearance.
Computational and mathematical methods in medicine
Jun 11, 2019
Hepatitis B surface antigen (HBsAg) seroclearance during treatment is associated with a better prognosis among patients with chronic hepatitis B (CHB). Significant gaps remain in our understanding on how to predict HBsAg seroclearance accurately and ...
Large-scale network analysis reveals the sequence space architecture of antibody repertoires.
Nature communications
Mar 21, 2019
The architecture of mouse and human antibody repertoires is defined by the sequence similarity networks of the clones that compose them. The major principles that define the architecture of antibody repertoires have remained largely unknown. Here, we...
Application of recurrent neural network for online prediction of cell density of recombinant Pichia pastoris producing HBsAg.
Preparative biochemistry & biotechnology
Feb 1, 2019
Artificial neural networking (ANN) seems to be a promising soft sensor for implementing current approaches of quality by design (QbD) and process analytical technologies (PAT) in the biopharmaceutical industry. In this study, we aimed to implement be...
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