Early detection of pancreatic cancer by comprehensive serum miRNA sequencing with automated machine learning.

Journal: British journal of cancer
PMID: 39198617

Abstract

BACKGROUND: Pancreatic cancer is often diagnosed at advanced stages, and early-stage diagnosis of pancreatic cancer is difficult because of nonspecific symptoms and lack of available biomarkers.

Authors

  • Munenori Kawai
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan.
  • Akihisa Fukuda
  • Ryo Otomo
    Research and Development Division, ARKRAY, Inc., Yousuien-nai, 59 Gansuin-cho, Kamigyo-ku, Kyoto, Japan.
  • Shunsuke Obata
    Research and Development Division, ARKRAY, Inc., Yousuien-nai, 59 Gansuin-cho, Kamigyo-ku, Kyoto, Japan.
  • Kosuke Minaga
    Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.
  • Masanori Asada
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan.
  • Atsushi Umemura
    Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Yoshito Uenoyama
    Department of Gastroenterology and Hepatology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
  • Nobuhiro Hieda
    Department of Gastroenterology, Otsu Red Cross Hospital, Shiga, Japan.
  • Toshihiro Morita
    Department of Gastroenterology and Hepatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.
  • Ryuki Minami
    Department of Gastroenterology, Tenri Hospital, Nara, Japan.
  • Saiko Marui
    Department of Gastroenterology and Hepatology, Shiga General Hospital, Shiga, Japan.
  • Yuki Yamauchi
    Department of Gastroenterology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
  • Yoshitaka Nakai
    Department of Gastroenterology and Hepatology, Kyoto Katsura Hospital, Kyoto, Japan.
  • Yutaka Takada
    Department of Gastroenterology and Hepatology, Kobe City Nishi-Kobe Medical Center, Kobe, Japan.
  • Kozo Ikuta
    Division of Gastroenterology, Shinko Hospital, Kobe, Japan.
  • Takuto Yoshioka
    Department of Gastroenterology and Hepatology, Takatsuki Red Cross Hospital, Takatsuki, Japan.
  • Kenta Mizukoshi
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan.
  • Kosuke Iwane
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan.
  • Go Yamakawa
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan.
  • Mio Namikawa
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan.
  • Makoto Sono
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan.
  • Munemasa Nagao
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan.
  • Takahisa Maruno
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan.
  • Yuki Nakanishi
    Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Kyoto Japan.
  • Mitsuharu Hirai
    Research and Development Division, ARKRAY, Inc., Yousuien-nai, 59 Gansuin-cho, Kamigyo-ku, Kyoto, Japan.
  • Naoki Kanda
    Department of Gastroenterology and Hepatology, Takatsuki Red Cross Hospital, Takatsuki, Japan.
  • Seiji Shio
    Division of Gastroenterology, Shinko Hospital, Kobe, Japan.
  • Toshinao Itani
    Department of Gastroenterology and Hepatology, Kobe City Nishi-Kobe Medical Center, Kobe, Japan.
  • Shigehiko Fujii
    Department of Gastroenterology and Hepatology, Kyoto Katsura Hospital, Kyoto, Japan.
  • Toshiyuki Kimura
    Department of Gastroenterology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
  • Kazuyoshi Matsumura
    Department of Gastroenterology and Hepatology, Shiga General Hospital, Shiga, Japan.
  • Masaya Ohana
    Department of Gastroenterology, Tenri Hospital, Nara, Japan.
  • Shujiro Yazumi
    Department of Gastroenterology and Hepatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.
  • Chiharu Kawanami
    Department of Gastroenterology, Otsu Red Cross Hospital, Shiga, Japan.
  • Yukitaka Yamashita
    Department of Gastroenterology and Hepatology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
  • Hiroyuki Marusawa
    Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan.
  • Tomohiro Watanabe
  • Yoshito Ito
    Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Masatoshi Kudo
  • Hiroshi Seno
    Department of Legal Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan.

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