Spatiotemporal discoordination of brain spontaneous activity in major depressive disorder.

Journal: Journal of affective disorders
PMID:

Abstract

BACKGROUND: Major depressive disorder (MDD) is a widespread mental health issue, impacting spatial and temporal aspects of brain activity. The neural mechanisms behind MDD remain unclear. To address this gap, we introduce a novel measure, spatiotemporal topology (SPT), capturing both the hierarchy and dynamic attributes of brain activity in depressive disorder patients.

Authors

  • Qunjun Liang
    Department of Medical Imaging, Huazhong University of Science and Technology Union Shenzhen Hospital, Taoyuan AVE 89, Nanshan District, Shenzhen 518000, People's Republic of China; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, People's Republic of China.
  • Ziyun Xu
    Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, China.
  • Shengli Chen
    Department of Medical Imaging, Huazhong University of Science and Technology Union Shenzhen Hospital, Taoyuan AVE 89, Nanshan District, Shenzhen 518000, People's Republic of China.
  • Shiwei Lin
    Department of Medical Imaging, Huazhong University of Science and Technology Union Shenzhen Hospital, Taoyuan AVE 89, Nanshan District, Shenzhen 518000, People's Republic of China.
  • Xiaoshan Lin
    Department of Medical Imaging, Huazhong University of Science and Technology Union Shenzhen Hospital, Taoyuan AVE 89, Nanshan District, Shenzhen 518000, People's Republic of China.
  • Ying Li
    School of Information Engineering, Chang'an University, Xi'an 710010, China.
  • Yingli Zhang
    Department of Depressive Disorder, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, Guangdong 518020, People's Republic of China.
  • Bo Peng
    Institute for Environmental and Climate Research, Jinan University, Guangzhou, China.
  • Gangqiang Hou
    Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, China. Electronic address: nihaohgq@163.com.
  • Yingwei Qiu
    Department of Medical Imaging, Huazhong University of Science and Technology Union Shenzhen Hospital, Taoyuan AVE 89, Nanshan District, Shenzhen 518000, People's Republic of China. Electronic address: qiuyw1201@gmail.com.