European cross-cultural neuropsychological test battery (CNTB) for the assessment of cognitive impairment in multiple sclerosis: Cognitive phenotyping and classification supported by machine learning techniques.

Journal: Multiple sclerosis and related disorders
PMID: 39366169

Abstract

BACKGROUND: The European Cross-Cultural Neuropsychological Test Battery (CNTB) has been proposed as a comprehensive battery for cognitive assessment, reducing the potential impact of cultural variables. In this validation study, we aimed to evaluate the diagnostic capacity of CNTB for the assessment of participants with multiple sclerosis (pwMS) compared to the Neuronorma battery (NN) according to the International Classification of Cognitive Disorders in MS criteria, and to develop machine learning (ML) algorithms to improve the diagnostic capacity of CNTB and to select the most relevant tests.

Authors

  • Alfonso Delgado-Álvarez
    Department of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdiSSC), Universidad Complutense, ES, Madrid 28040, Spain; Department of Biological and Health Psychology, Faculty of Psychology, Universidad Autónoma de Madrid, Madrid, Spain.
  • Laura Hernández-Lorenzo
    Department of Neurology, Hospital Clinico San Carlos, San Carlos Research Health Institute (IdISSC), Universidad Complutense, Madrid, Spain.
  • T Rune Nielsen
    Danish Dementia Research Centre, Department of Neurology, University of Copenhagen-Rigshospitalet, Copenhagen, Denmark.
  • María Díez-Cirarda
    Department of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdiSSC), Universidad Complutense, ES, Madrid 28040, Spain.
  • Constanza Cuevas
    Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
  • Paloma Montero-Escribano
    Department of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdiSSC), Universidad Complutense, ES, Madrid 28040, Spain.
  • Cristina Delgado-Alonso
    Department of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdiSSC), Universidad Complutense, ES, Madrid 28040, Spain.
  • María Valles-Salgado
    Department of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdiSSC), Universidad Complutense, ES, Madrid 28040, Spain.
  • María José Gil-Moreno
    Department of Neurology, Hospital Clinico San Carlos, San Carlos Institute for Health Research (IdiSSC), Universidad Complutense, ES, Madrid 28040, Spain.
  • Jorge Matias-Guiu
    Department of Neurology, Hospital Clinico San Carlos, San Carlos Research Health Institute (IdISSC), Universidad Complutense, Madrid, Spain.
  • Jordi A Matias-Guiu
    Department of Neurology, Hospital Clinico San Carlos, San Carlos Research Health Institute (IdISSC), Universidad Complutense, Madrid, Spain.

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