Application of a deep-learning marker for morbidity and mortality prediction derived from retinal photographs: a cohort development and validation study.

Journal: The lancet. Healthy longevity
PMID:

Abstract

BACKGROUND: Biological ageing markers are useful to risk stratify morbidity and mortality more precisely than chronological age. In this study, we aimed to develop a novel deep-learning-based biological ageing marker (referred to as RetiPhenoAge hereafter) using retinal images and PhenoAge, a composite biomarker of phenotypic age.

Authors

  • Simon Nusinovici
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Tyler Hyungtaek Rim
    Department of Ocular Epidemiology, Singapore Eye Research Institute, Singapore, Singapore.
  • Hengtong Li
    Department of Ophthalmology and Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Marco Yu
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Mihir Deshmukh
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Ten Cheer Quek
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
  • Geunyoung Lee
    MediWhale, Seoul, South Korea.
  • Crystal Chun Yuen Chong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Qingsheng Peng
    Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China.
  • Can Can Xue
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Zhuoting Zhu
    Department of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China.
  • Emily Y Chew
    National Eye Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: echew@nei.nih.gov.
  • Charumathi Sabanayagam
    Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
  • Tien-Yin Wong
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
  • Yih-Chung Tham
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore.
  • Ching-Yu Cheng
    Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.