Deep Learning Virtual Contrast-Enhanced T1 Mapping for Contrast-Free Myocardial Extracellular Volume Assessment.

Journal: Journal of the American Heart Association
PMID:

Abstract

BACKGROUND: The acquisition of contrast-enhanced T1 maps to calculate extracellular volume (ECV) requires contrast agent administration and is time consuming. This study investigates generative adversarial networks for contrast-free, virtual extracellular volume (vECV) by generating virtual contrast-enhanced T1 maps.

Authors

  • Sebastian Nowak
    From the Quantitative Imaging Lab, Department of Radiology.
  • Leon M Bischoff
    From the Department of Diagnostic and Interventional Radiology (L.M.B., A.I., D.K., U.A., C.C.P., A.M.S., J.A.L.), Quantitative Imaging Laboratory Bonn (QILaB) (L.M.B., A.I., D.K., A.M.S., J.A.L.), Institute for Medical Biometry, Informatics and Epidemiology (L.W.), and Department of Urology (P.K., J.E.), University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany; Philips MR Clinical Science, Best, the Netherlands (J.M.P.); and Philips Market DACH, Hamburg, Germany (C.K., O.M.W.).
  • Lenhard Pennig
    Institute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.
  • Kenan Kaya
    Department of Diagnostic and Interventional Radiology University Hospital Cologne Cologne Germany.
  • Alexander Isaak
    From the Department of Diagnostic and Interventional Radiology (L.M.B., A.I., D.K., U.A., C.C.P., A.M.S., J.A.L.), Quantitative Imaging Laboratory Bonn (QILaB) (L.M.B., A.I., D.K., A.M.S., J.A.L.), Institute for Medical Biometry, Informatics and Epidemiology (L.W.), and Department of Urology (P.K., J.E.), University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany; Philips MR Clinical Science, Best, the Netherlands (J.M.P.); and Philips Market DACH, Hamburg, Germany (C.K., O.M.W.).
  • Maike Theis
    Department of Diagnostic and Interventional Radiology, Quantitative Imaging Lab Bonn (QILaB), University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
  • Wolfgang Block
    From the Quantitative Imaging Lab, Department of Radiology.
  • Claus C Pieper
    Department of Diagnostic and Interventional Radiology, Quantitative Imaging Lab Bonn (QILaB), University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
  • Daniel Kuetting
    From the Department of Diagnostic and Interventional Radiology (L.M.B., A.I., D.K., U.A., C.C.P., A.M.S., J.A.L.), Quantitative Imaging Laboratory Bonn (QILaB) (L.M.B., A.I., D.K., A.M.S., J.A.L.), Institute for Medical Biometry, Informatics and Epidemiology (L.W.), and Department of Urology (P.K., J.E.), University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany; Philips MR Clinical Science, Best, the Netherlands (J.M.P.); and Philips Market DACH, Hamburg, Germany (C.K., O.M.W.).
  • Sebastian Zimmer
    Department of Internal Medicine II, Heart Center University Hospital Bonn Bonn Germany.
  • Georg Nickenig
    Department of Internal Medicine II, Heart Center University Hospital Bonn Bonn Germany.
  • Ulrike I Attenberger
    Department of Diagnostic and Interventional Radiology, Quantitative Imaging Lab Bonn (QILaB), University Hospital Bonn (Universitätsklinikum Bonn), Venusberg-Campus 1, 53127, Bonn, Germany.
  • Alois M Sprinkart
    From the Quantitative Imaging Lab, Department of Radiology.
  • Julian A Luetkens
    Department of Radiology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.