Non-invasive multimodal CT deep learning biomarker to predict pathological complete response of non-small cell lung cancer following neoadjuvant immunochemotherapy: a multicenter study.

Journal: Journal for immunotherapy of cancer
PMID:

Abstract

OBJECTIVES: Although neoadjuvant immunochemotherapy has been widely applied in non-small cell lung cancer (NSCLC), predicting treatment response remains a challenge. We used pretreatment multimodal CT to explore deep learning-based immunochemotherapy response image biomarkers.

Authors

  • Guanchao Ye
    Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Guangyao Wu
    Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Yu Qi
    Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Kuo Li
    Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (G.Y., K.L., C.Z., Y.L.).
  • Mingliang Wang
    Faculty of Psychology, Tianjin Normal University, Tianjin, China.
  • Chunyang Zhang
    1 The Nursing College of Zhengzhou University, Zhengzhou 450052, China ; 2 Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
  • Feng Li
    Department of General Surgery, Shanghai Traditional Chinese Medicine (TCM)-INTEGRATED Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Leonard Wee
    Maastricht University Medical Centre, Netherlands.
  • Andre Dekker
    Department of Radiation Oncology (MAASTRO Clinic), Dr. Tanslaan 12, Maastricht, The Netherlands.
  • Chu Han
  • Zaiyi Liu
    Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Yongde Liao
    Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhenwei Shi
    Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Development Biology, Maastricht University Medical Centre+, Maastricht, 6229 ET, The Netherlands.