AIMC Topic: Immunotherapy
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Artificial intelligence-based digital pathology using H&E-stained whole slide images in immuno-oncology: from immune biomarker detection to immunotherapy response prediction.
Journal for immunotherapy of cancer
Aug 4, 2025
Immuno-oncology and the advent of immunotherapies, in particular immune checkpoint inhibitors (ICIs), have fundamentally altered the way we treat cancer. Yet only a small subset of patients actually responds to ICIs, and many face significant adverse...
Mitochondrial Pathway Signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma.
Journal for immunotherapy of cancer
Jul 31, 2025
BACKGROUND: Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Although immune checkpoint inhibitors (ICIs) have brought new treatment options for advanced patients, a considerable proportion still shows limited resp...
Gut microbiota and SCFAs improve the treatment efficacy of chemotherapy and immunotherapy in NSCLC.
NPJ biofilms and microbiomes
Jul 28, 2025
The role of gut dysbiosis in shaping immunotherapy responses is well-recognized, yet its effect on the therapeutic efficacy of chemotherapy and immunotherapy combinations remains poorly understood. We analyzed gut microbiota in non-small cell lung ca...
Machine-learning driven strategies for adapting immunotherapy in metastatic NSCLC.
Nature communications
Jul 24, 2025
Immune checkpoint inhibitors (ICIs), either as monotherapy (ICI-Mono) or combined with chemotherapy (ICI-Chemo), improves survival in advanced non-small cell lung cancer (NSCLC). However, prospective guidance for choosing between these options remain...
Beyond the native repertoire.
Science (New York, N.Y.)
Jul 24, 2025
Design of T cell receptors by artificial intelligence is poised to accelerate cancer immunotherapy.
Integrative habitat analysis and multi-instance deep learning for predictive model of PD-1/PD-L1 immunotherapy efficacy in NSCLC patients: a dual-center retrospective study.
BMC medical imaging
Jul 17, 2025
BACKGROUND: PD-1/PD-L1 immunotherapy represents the primary treatment for advanced NSCLC patients; however, response rates to this therapy vary among individuals. This dual-center study aimed to integrate habitat radiomics and multi-instance deep lea...
Integrative analysis of multi-omics data and gut microbiota composition reveals prognostic subtypes and predicts immunotherapy response in colorectal cancer using machine learning.
Scientific reports
Jul 12, 2025
Colorectal cancer (CRC) exhibits substantial heterogeneity in molecular subtypes and clinical outcomes. We performed an integrative analysis of multi-omics data from 274 CRC patients to investigate the impact of gut microbiota composition on prognosi...
USP5-Mediated PD-L1 deubiquitination regulates immunotherapy efficacy in melanoma.
Journal of translational medicine
Jul 10, 2025
BACKGROUND: The role of post-translational modifications(PTMs) in PD-L1-mediated immune resistance and melanoma progression remains poorly understood.
Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML.
Science advances
Jul 9, 2025
Given the graft-versus-leukemia effect observed with allogeneic hematopoietic stem cell transplantation in refractory or relapsed acute myeloid leukemia (AML), immunotherapies have been explored in nontransplant settings. We applied a multiomic appro...
Cancer Research in the 21st Century: Recent Advances and Future Perspectives.
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Jul 9, 2025
INTRODUCTION: Cancer remains a major global health concern, accounting for nearly 10 million deaths annually. Despite its complexity and heterogeneity, significant advancements in cancer research over the past two decades have transformed the landsca...
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