Recent Advances in Artificial Intelligence to Improve Immunotherapy and the Use of Digital Twins to Identify Prognosis of Patients with Solid Tumors.

Journal: International journal of molecular sciences
Published Date:

Abstract

To date, the public health system has been impacted by the increasing costs of many diagnostic and therapeutic pathways due to limited resources. At the same time, we are constantly seeking to improve these paths through approaches aimed at personalized medicine. To achieve the required levels of diagnostic and therapeutic precision, it is necessary to integrate data from different sources and simulation platforms. Today, artificial intelligence (AI), machine learning (ML), and predictive computer models are more efficient at guiding decisions regarding better therapies and medical procedures. The evolution of these multiparametric and multimodal systems has led to the creation of digital twins (DTs). The goal of our review is to summarize AI applications in discovering new immunotherapies and developing predictive models for more precise immunotherapeutic decision-making. The findings from this literature review highlight that DTs, particularly predictive mathematical models, will be pivotal in advancing healthcare outcomes. Over time, DTs will indeed bring the benefits of diagnostic precision and personalized treatment to a broader spectrum of patients.

Authors

  • Laura D'Orsi
    National Research Council of Italy, Institute for Systems Analysis and Computer Science "A. Ruberti", BioMatLab, Via dei Taurini, 19, 00185 Rome, RM, Italy.
  • Biagio Capasso
    Department of General Surgery, Policlinico Militare di Roma "Celio", Piazza Celimontana, 50, 00184 Rome, RM, Italy.
  • Giuseppe Lamacchia
    General Surgery Unit, Regina Apostolorum Hospital, Via S. Francesco d'Assisi, 50, 00041 Albano Laziale, RM, Italy.
  • Paolo Pizzichini
    Department of Intensive Care Unit, Policlinico Militare di Roma "Celio", Piazza Celimontana, 50, 00184 Rome, RM, Italy.
  • Sergio Ferranti
    Department of General Surgery, Policlinico Militare di Roma "Celio", Piazza Celimontana, 50, 00184 Rome, RM, Italy.
  • Andrea Liverani
    General Surgery Unit, Regina Apostolorum Hospital, Via S. Francesco d'Assisi, 50, 00041 Albano Laziale, RM, Italy.
  • Costantino Fontana
    Department of Intensive Care Unit, Policlinico Militare di Roma "Celio", Piazza Celimontana, 50, 00184 Rome, RM, Italy.
  • Simona Panunzi
    National Research Council of Italy, Institute for Systems Analysis and Computer Science "A. Ruberti", BioMatLab, Via dei Taurini, 19, 00185 Rome, RM, Italy.
  • Andrea De Gaetano
    National Research Council of Italy, Institute for Systems Analysis and Computer Science "A. Ruberti", BioMatLab, Via dei Taurini, 19, 00185 Rome, RM, Italy.
  • Elena Lo Presti
    National Research Council of Italy, Institute for Biomedical Research and Innovation (CNR-IRIB), Via Ugo La Malfa, 153, 90146 Palermo, PA, Italy.