Small, dense high-density lipoprotein 3 particles exhibit defective antioxidative and anti-inflammatory function in familial hypercholesterolemia: Partial correction by low-density lipoprotein apheresis.

Journal: Journal of clinical lipidology
PMID: 26892129

Abstract

BACKGROUND: Familial hypercholesterolemia (FH) features elevated oxidative stress and accelerated atherosclerosis driven by elevated levels of atherogenic lipoproteins relative to subnormal levels of atheroprotective high-density lipoprotein (HDL). Small, dense HDL3 potently protects low-density lipoprotein (LDL) against proinflammatory oxidative damage.

Authors

  • Hala Hussein
    Université Pierre et Marie Curie-Paris 6, Paris, France; AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France; National Institute for Health and Medical Research (INSERM), Paris, France.
  • Samir Saheb
    AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France.
  • Martine Couturier
    National Institute for Health and Medical Research (INSERM), Paris, France; Hôpital Bicetre, Bicetre, France.
  • Marielle Atassi
    AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France.
  • Alexina Orsoni
    Université Pierre et Marie Curie-Paris 6, Paris, France; AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France; National Institute for Health and Medical Research (INSERM), Paris, France.
  • Alain Carrié
    Université Pierre et Marie Curie-Paris 6, Paris, France; AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France; National Institute for Health and Medical Research (INSERM), Paris, France.
  • Patrice Therond
    Hôpital Bicetre, Bicetre, France.
  • Sandrine Chantepie
    Université Pierre et Marie Curie-Paris 6, Paris, France; AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France; National Institute for Health and Medical Research (INSERM), Paris, France.
  • Paul Robillard
    Université Pierre et Marie Curie-Paris 6, Paris, France; AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France; National Institute for Health and Medical Research (INSERM), Paris, France.
  • Eric Bruckert
    AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France.
  • M John Chapman
    Université Pierre et Marie Curie-Paris 6, Paris, France; AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France; National Institute for Health and Medical Research (INSERM), Paris, France.
  • Anatol Kontush
    Université Pierre et Marie Curie-Paris 6, Paris, France; AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France; National Institute for Health and Medical Research (INSERM), Paris, France. Electronic address: anatol.kontush@upmc.fr.

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