Prediction model for ocular metastasis of breast cancer: machine learning model development and interpretation study.

Journal: BMC cancer
PMID: 39614215

Abstract

BACKGROUND: Breast cancer (BC) is caused by the uncontrolled proliferation of breast epithelial cells followed by malignant transformation, and it has the highest incidence among female malignant tumors. The metastasis of BC occurs through direct and lymphatic spread. Although ocular metastasis is relatively rare, it is a good indicator of a worse prognosis. We used machine learning (ML) to establish a model to analyze the risk factors of BC eye metastasis.

Authors

  • Ru-Yi Rong
    Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
  • Yan-Kun Shen
    Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
  • Shi-Nan Wu
    Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
  • San-Hua Xu
    Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
  • Jin-Yu Hu
    Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
  • Jie Zou
    Institute of Intelligent Control and Robotics, Hangzhou Dianzi University, Hangzhou, Zhejiang, 310018, China.
  • Liangqi He
    Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
  • Cheng Chen
    Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, China.
  • Min Kang
    Department of Computer Engineering, Gachon University, Sungnam-si 13306, Korea.
  • Ping Ying
    Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
  • Hong Wei
    Department of Materials Science and Engineering, University of California, Irvine, California 92697, United States.
  • Qian Ling
    Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
  • Qian-Ming Ge
    Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
  • Yan Lou
    Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, Zhejiang, China.
  • Yi Shao
    Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Disease, Shanghai, China.

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