Tuberculous Pericarditis is Multibacillary and Bacterial Burden Drives High Mortality.

Journal: EBioMedicine
Published Date:

Abstract

BACKGROUND: Tuberculous pericarditis is considered to be a paucibacillary process; the large pericardial fluid accumulation is attributed to an inflammatory response to tuberculoproteins. Mortality rates are high. We investigated the role of clinical and microbial factors predictive of tuberculous pericarditis mortality using the artificial intelligence algorithm termed classification and regression tree (CART) analysis.

Authors

  • Jotam G Pasipanodya
    Center for Infectious Diseases Research & Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, TX, USA.
  • Mwenya Mubanga
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
  • Mpiko Ntsekhe
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
  • Shaheen Pandie
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
  • Beki T Magazi
    National Health Laboratory Services (Tshwane Academic Division), Department of Medical Microbiology, University of Pretoria, South Africa.
  • Freedom Gumedze
    Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa.
  • Landon Myer
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
  • Tawanda Gumbo
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa; Center for Infectious Diseases Research & Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, TX, USA.
  • Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.