AIMC Topic: Comorbidity

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An exploratory machine learning study on paediatric abdominal pain phenotyping and prediction.

PloS one
BACKGROUND: The exact mechanisms underlying paediatric abdominal pain (AP) remain unclear due to patient heterogeneity. This preliminary study aimed to identify AP phenotypes and develop predictive models to explore associated factors, with the goal ...

Using unsupervised machine learning methods to cluster cardio-metabolic profile of the middle-aged and elderly Chinese with general and central obesity.

BMC cardiovascular disorders
BACKGROUND: Obesity is a disease with high heterogeneity. Both overall obesity and central obesity are associated with increased risks of having cardio-metabolic co-morbidities. This study is aimed to examine the cardio-metabolic characteristics and ...

Identification of clinically meaningful, overlapping obstructive respiratory disease subtypes via data-driven approaches in a primary care population.

BMC pulmonary medicine
BACKGROUND: Obstructive respiratory conditions, including asthma, bronchiectasis, and chronic obstructive pulmonary disease (COPD), are increasingly recognised as heterogeneous syndromes with significant overlap. Multiple disease pathways contribute ...

Predicting All-Cause Mortality in Diabetic Patients 2 Years in Advance Using Aggregated EHR Data and Machine Learning.

Journal of medical systems
This study presents a machine learning-driven model predicting all-cause mortality two years in advance using administrative health data focused on diabetic patients. Integrating hospitalization records, emergency department data, demographics, and c...

The Impact of Comorbidity Patterns on Clinical Outcomes in Heart Failure: A Machine Learning-Based Cluster Analysis.

The American journal of cardiology
Heart failure (HF) is a major global health burden, and complex comorbidity patterns can worsen clinical outcomes and complicate patient care. This study aimed to identify distinct comorbidity-based clusters among HF patients and evaluate their assoc...

Data-driven identification of subgroups in early rheumatoid arthritis: mortality and cardiovascular disease in a cohort from western Norway.

RMD open
AIM: To identify subgroups of early rheumatoid arthritis (RA) based on comorbidities and RA manifestations and to investigate their associated risks of cardiovascular events and mortality.

Alzheimer's disease risk prediction using machine learning for survival analysis with a comorbidity-based approach.

Scientific reports
Alzheimer's disease (AD) presents a pressing global health challenge, demanding improved strategies for early detection and understanding its progression. In this study, we address this need by employing survival analysis techniques to predict transi...

Exploring the comorbidity mechanisms of ITGB2 in rheumatoid arthritis and membranous nephropathy through integrated bioinformatics analysis.

Renal failure
BACKGROUND: Patients with rheumatoid arthritis (RA) are more likely to comorbid renal diseases, with membranous nephropathy (MN) being the most common. This study aimed to explore the common pathogenesis between RA and MN using integrated bioinformat...

Association Between Comorbidity Clusters and Mortality in Patients With Cancer: Predictive Modeling Using Machine Learning Approaches of Data From the United States and Hong Kong.

JMIR cancer
BACKGROUND: Patients with cancer and cancer survivors often experience multiple chronic health conditions, which can impact symptom burden and treatment outcomes. Despite the high prevalence of multimorbidity, research on cancer prognosis has predomi...

Development and validation of a risk prediction model for depression in patients with chronic obstructive pulmonary disease.

BMC psychiatry
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a prevalent respiratory condition often accompanied by depression, which exacerbates disease burden and impairs quality of life. Early identification of depression risk in COPD patients rema...