Time-dependent personalized prognostic analysis by machine learning in biochemical recurrence after radical prostatectomy: a retrospective cohort study.

Journal: BMC cancer
PMID:

Abstract

BACKGROUND: For biochemical recurrence following radical prostatectomy for prostate cancer, treatments such as radiation therapy and androgen deprivation therapy are administered. To diagnose postoperative recurrence as early as possible and to intervene with treatment at the appropriate time, it is essential to accurately predict recurrence after radical prostatectomy. However, postoperative recurrence involves numerous patient-related factors, making its prediction challenging. The purpose of this study is to accurately predict the timing of biochemical recurrence after radical prostatectomy and to analyze the risk factors for follow-up of high-risk patients and early detection of recurrence.

Authors

  • Kodai Sato
    Department of Urology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoku, Chiba-shi, Chiba, 260-8670, Japan.
  • Shinichi Sakamoto
    Department of Urology, Chiba University Hospital, Chiba, Japan.
  • Shinpei Saito
    Department of Urology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoku, Chiba-shi, Chiba, 260-8670, Japan.
  • Hiroki Shibata
    Department of Urology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoku, Chiba-shi, Chiba, 260-8670, Japan.
  • Yasutaka Yamada
    Department of Urology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoku, Chiba-shi, Chiba, 260-8670, Japan.
  • Nobuyoshi Takeuchi
    Department of Urology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoku, Chiba-shi, Chiba, 260-8670, Japan.
  • Yusuke Goto
    Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Sazuka Tomokazu
    Department of Urology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoku, Chiba-shi, Chiba, 260-8670, Japan.
  • Yusuke Imamura
    Department of Urology, Chiba University Hospital, Chiba, Japan.
  • Tomohiko Ichikawa
    Department of Urology, Chiba University Hospital, Chiba, Japan.
  • Eiryo Kawakami
    Medical Sciences Innovation Hub Program, RIKEN, Yokohama, Kanagawa, Japan.