Analysis of the relationships between interferon-stimulated genes and anti-SSA/Ro 60 antibodies in primary Sjögren's syndrome patients via multiomics and machine learning methods.

Journal: International immunopharmacology
PMID: 39577221

Abstract

BACKGROUND: Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocyte infiltration of the exocrine glands. Interferon-stimulated genes (ISGs) are often upregulated in patients with pSS, and anti-SSA/Ro 60 antibodies are among the main items detected in pSS. However, the relationship between ISGs and anti-SSA/Ro 60 antibodies in pSS remains unclear. Therefore, our study aimed to explore the relationships between ISGs and anti-SSA/Ro 60 antibodies and identify key genes involved in pSS.

Authors

  • Jinkun Liu
    Chongqing Key Laboratory of Traditional Chinese Medicine to Prevent and Treat Autoimmune Diseases, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, PR China; First Affiliated Hospital of Chongqing University of Chinese Medicine, Chongqing University of Chinese Medicine, Chongqing 400021, PR China.
  • Jing Feng
    Department of Urology, ZhongNan Hospital, Wuhan University, No. 169 Donghu Road, Wuhan, Hubei, 430071, China.
  • Fenglin Zhu
    First Affiliated Hospital of Chongqing University of Chinese Medicine, Chongqing University of Chinese Medicine, Chongqing 400021, PR China; Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, PR China.
  • Yingzhou Chen
    First Affiliated Hospital of Chongqing University of Chinese Medicine, Chongqing University of Chinese Medicine, Chongqing 400021, PR China; Pathology Department, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, PR China.
  • Jingru Chen
    First Affiliated Hospital of Chongqing University of Chinese Medicine, Chongqing University of Chinese Medicine, Chongqing 400021, PR China; Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, PR China.
  • Yanhui Li
    Departments of Cardiology and Echocardiography, The First Hospital of Jilin University, Changchun 130021, China.
  • Min Ying
    Chongqing Cancer Multi-omics Big Data Application Engineering Research Center, Chongqing University Cancer Hospital, Chongqing 400030, PR China. Electronic address: candymin89@126.com.
  • Bin Wu
    Department of Psychiatry, Xi'an Mental Health Center, Xi'an, China.

Keywords

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