AIMC Topic: RNA, Small Cytoplasmic

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Analysis of the relationships between interferon-stimulated genes and anti-SSA/Ro 60 antibodies in primary Sjögren's syndrome patients via multiomics and machine learning methods.

International immunopharmacology Nov 21, 2024
BACKGROUND: Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocyte infiltration of the exocrine glands. Interferon-stimulated genes (ISGs) are often upregulated in patients with pSS, and anti-SSA/Ro 60 a...
Humans Machine Learning Female Adult Male Middle Aged Leukocytes, Mononuclear Gene Expression Profiling Transcriptome Multiomics Autoantibodies Autoantigens Sjogren's Syndrome Interferons RNA, Small Cytoplasmic Antibodies, Antinuclear Ribonucleoproteins
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coupleCoC+: An information-theoretic co-clustering-based transfer learning framework for the integrative analysis of single-cell genomic data.

PLoS computational biology Jun 2, 2021
Technological advances have enabled us to profile multiple molecular layers at unprecedented single-cell resolution and the available datasets from multiple samples or domains are growing. These datasets, including scRNA-seq data, scATAC-seq data and...
Humans Machine Learning Software Animals Dendritic Cells Single-Cell Analysis RNA-Seq Mice Genomics Computational Biology Cluster Analysis Cerebral Cortex Databases, Nucleic Acid Information Theory RNA, Small Cytoplasmic
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SuperCT: a supervised-learning framework for enhanced characterization of single-cell transcriptomic profiles.

Nucleic acids research May 7, 2019
Characterization of individual cell types is fundamental to the study of multicellular samples. Single-cell RNAseq techniques, which allow high-throughput expression profiling of individual cells, have significantly advanced our ability of this task....
Humans Software Animals Gene Expression Profiling Transcriptome Single-Cell Analysis Mice Sequence Analysis, RNA Gene Expression Regulation, Neoplastic Cluster Analysis Pancreatic Neoplasms Supervised Machine Learning High-Throughput Nucleotide Sequencing Datasets as Topic Cell Lineage RNA, Small Cytoplasmic
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