Using Machine Learning Models to Predict Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer.

Journal: JCO clinical cancer informatics
PMID:

Abstract

PURPOSE: Neoadjuvant chemotherapy (NAC) is increasingly used in breast cancer. Predictive modeling is useful in predicting pathologic complete response (pCR) to NAC. We test machine learning (ML) models to predict pCR in breast cancer and explore methods of handling missing data.

Authors

  • Rayhan Erlangga Rahadian
    Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
  • Hong Qi Tan
    Division of Radiation Oncology, National Cancer Centre Singapore, Singapore Health Services, Singapore, Singapore.
  • Bryan Shihan Ho
    Division of Radiation Oncology, National Cancer Centre Singapore, Singapore Health Services, Singapore, Singapore.
  • Arjunan Kumaran
    Division of Radiation Oncology, National Cancer Centre Singapore, Singapore Health Services, Singapore, Singapore.
  • Andre Villanueva
    Division of Radiation Oncology, National Cancer Centre Singapore, Singapore Health Services, Singapore, Singapore.
  • Joy Sng
    Division of Radiation Oncology, National Cancer Centre Singapore, Singapore Health Services, Singapore, Singapore.
  • Ryan Shea Ying Cong Tan
    Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
  • Tira Jing Ying Tan
    Division of Medical Oncology, National Cancer Centre Singapore, Singapore Health Services, Singapore, Singapore.
  • Veronique Kiak Mien Tan
    Division of Breast Surgery, Singapore General Hospital, Singapore Health Services, Singapore, Singapore.
  • Benita Kiat Tee Tan
    Division of Breast Surgery, Sengkang General Hospital, Singapore Health Services, Singapore, Singapore.
  • Geok Hoon Lim
    Breast Department, KK Women's and Children's Hospital, Singapore, Singapore.
  • Yiyu Cai
    School of Mechanical and Aerospace Engineering, College of Engineering, Nanyang Technological University, Singapore, Singapore.
  • Wen Long Nei
    Division of Radiation Oncology, National Cancer Centre Singapore, Singapore Health Services, Singapore, Singapore.
  • Fuh Yong Wong
    Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore.