Comparison of Manual vs Artificial Intelligence-Based Muscle MRI Segmentation for Evaluating Disease Progression in Patients With CMT1A.

Journal: Neurology
Published Date:

Abstract

BACKGROUND AND OBJECTIVES: Intramuscular fat fraction (FF), assessed with quantitative MRI (qMRI), has emerged as one of the few responsive outcome measures in CMT1A patients. The main limitation for its use in future therapeutic trials is the time required for the manual segmentation of individual muscles. This study aimed to evaluate the accuracy and responsiveness of a fully automatic artificial intelligence (AI)-based segmentation pipeline to assess disease progression in a cohort of CMT1A patients over 1 year.

Authors

  • Etienne Fortanier
    Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, Marseille, France.
  • Marc Adrien Hostin
    From the Reference Center for Neuromuscular Diseases and ALS (E.F., E.D., S.A.), La Timone University Hospital, Marseille; UMR CNRS 7339 (E.F., C.P.M., M.G., D.B.), Center for Magnetic Resonance in Biology and Medicine, Marseille; CNRS, LIS (M.A.H., M.-E.B.), UMR 7286, Medicine Faculty (E.D.), and Inserm, GMGF (S.A.), Aix-Marseille University, France.
  • Constance P Michel
    Aix Marseille University, CNRS, CRMBM, Marseille, France.
  • Emilien Delmont
    From the Reference Center for Neuromuscular Diseases and ALS (E.F., E.D., S.A.), La Timone University Hospital, Marseille; UMR CNRS 7339 (E.F., C.P.M., M.G., D.B.), Center for Magnetic Resonance in Biology and Medicine, Marseille; CNRS, LIS (M.A.H., M.-E.B.), UMR 7286, Medicine Faculty (E.D.), and Inserm, GMGF (S.A.), Aix-Marseille University, France.
  • Maxime Guye
    From the Neuroimaging of Epilepsy Laboratory (R.S.G., H.-M.L., B.C., S.-J.H., N.B., A.B.), Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; Pediatric Neurology Unit and Laboratories (C.B., M.L., R.G.), Children's Hospital A. Meyer-University of Florence, Italy; Epilepsy Unit (F.D.) and Neuroradiology (L.D.), Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy; Department of Neurology (V.C.M.C., F.C.), University of Campinas, Brazil; The Florey Institute of Neuroscience and Mental Health and The University of Melbourne (M.S., G.J.), Victoria, Australia; Department of Pediatrics (D.V.S.), British Columbia Children's Hospital, Vancouver, Canada; Aix Marseille University (F.B.), INSERM UMR 1106, Institut de Neurosciences des Systèmes; Aix Marseille University (M.G.), CNRS, CRMBM UMR 7339, Marseille, France; Freiburg Epilepsy Center (A.S.-B., H.U.), Universitätsklinikum Freiburg, Germany; Department of Neurology (K.H.C.), Yonsei University College of Medicine, Seoul, Korea; and Department of Neurology (R.E.H.), Washington University School of Medicine, St. Louis, MO.
  • Marc-Emmanuel Bellemare
    Aix Marseille University, CNRS, LIS, Marseille, France.
  • Shahram Attarian
    Reference Center for Neuromuscular Diseases and ALS, APHM, University Hospital of Marseille/Timone University Hospital, Marseille, France.
  • David Bendahan
    Aix-Marseille Universite, CNRS, Centre de Résonance Magnétique Biologique et Médicale, UMR, Marseille, France.